Lamin A antibody

Product name : Lamin A antibody

Catalog number : 70R-21586

Supplier : fitzgerald

Price : 512 EUR

Size : 50 µl

More about:

Classification : Lamins

Concept : Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

Discovery year : 1992-04-09

Entrez Gene : lamin B1  (LMNB1)

Entrez gene record : 4000

GenBank acession : BC014507

Gene : LMNA

Gene ontology - Biological process : interleukin-12-mediated signaling pathway

Gene ontology - Cellular component : nucleus nucleoplasm membrane nuclear envelope nuclear inner membrane lamin filament nuclear matrix nuclear membrane

Gene ontology - Molecular function : protein binding structural molecule activity phospholipase binding

Havana BLAST/BLAT : OTTHUMG00000013961

Identity : 6636

InterPro : Lamin Tail Domain  (LMNTD1) Lamin B-type Intermediate filament protein  (SYNC) Intermediate filament protein, conserved site

Kegg : Apoptosis - Homo sapiens (human)

Locus : 1q22

Locus Specific Databases : Inherited Peripheral Neuropathies Mutation Database Leiden Muscular Dystrophy Pages UMD Locus Specific Databases Leiden Muscular Dystrophy pages LRG_254

Long gene name : lamin A/C

Name : Blotting, Western

PubMed : Apoptotic neutrophils express lamin B1 on their surface; these cells may participate in the development of autoantibodies directed against cytoskeletal proteins, a condition frequently reported in several inflammatory diseases. Results suggest that the C-terminus of nuclear titin binds lamins A and B in vivo and might contribute to nuclear organization during interphase. LB1 expression in WI-38 cells decreases during cellular senescence Lamin B1 is lost from primary human and murine cell strains when they are induced to senesce. LMNB1 protein levels decline in senescent human dermal fibroblasts and keratinocytes, mediated by reduced transcription and inhibition of LMNB1 messenger ribonucleic acid translation by miRNA-23a. Rare variants of LMNB1 may contribute to susceptibility to neural tube defects. lamin B1 down-regulation in senescence is a key trigger of global and local chromatin changes that impact gene expression, aging, and cancer LMNB1 may contribute to senescence in at least two ways due to its uneven genome-wide redistribution: first, through the spatial reorganization of chromatin and, second, through gene repression. LMNB1 is required to maintain chromatin condensation in interphase nuclei. maintenance of lamin B1 levels is required for DNA replication and repair through regulation of the expression of key factors involved in these essential nuclear functions

Pubmed identfication : 8511676 8838815 12702809

Qualifiers : classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics

RefSeq identity : NM_170707

Synonyms : HGPS MADA

Synonyms gene : LMN1 CMD1A LGMD1B PRO1 LMNL1

Synonyms gene name : cardiomyopathy, dilated 1A (autosomal dominant) limb girdle muscular dystrophy 1B (autosomal dominant) progeria 1 (Hutchinson-Gilford type) lamin A/C-like 1

Synonyms name : mandibuloacral dysplasia type A

Tree numbers : E05.196.401.143 E05.301.300.096 E05.478.566.320.200 E05.601.262 E05.601.470.320.200

WikiPathWays : Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation