Anti- GZMK Antibody

Product name : Anti- GZMK Antibody

Catalog number : GEN2517464

Supplier : MBS Polyclonals

Price : 348 EUR

Size : 0.12 ml

More about:

Concept : Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

Discovery year : 1995-08-31

Entrez Gene : granzyme K  (GZMK)

Entrez gene record : 3003

GenBank acession : BC035802

Gene : GZMK

Gene ontology - Biological process : proteolysis

Gene ontology - Cellular component : extracellular region

Gene ontology - Molecular function : serine-type endopeptidase activity serine-type peptidase activity

Havana BLAST/BLAT : OTTHUMG00000097009

Identity : 4711

InterPro : Peptidase S1, PA clan Serine proteases, trypsin family, serine active site Serine proteases, trypsin family, histidine active site Peptidase S1A, chymotrypsin family Serine proteases, trypsin domain

Locus : 5q11.2

Long gene name : granzyme K

Name : Blotting, Western

PubMed : Carbamate pesticides significantly reduced the intracellular levels of perforin, GrA, GrB, Gr3/K, and GRN in NK-92CI cells. GzmK-induced caspase-independent death occurs through Bid-dependent mitochondrial damage that is different from GzmA p53 is as a cytotoxic bomb that can be triggered by granzyme K, leading to potentiating killing efficacy. Natural killer (NK)-92 cell line retains the functional characteristics of the CD56(bright) NK cell subset; consequently, gene silencing of CD56 profoundly inhibits the ability of NK-92 cells to kill activated syngeneic T cells. Extracellular granzyme K mediates endothelial activation through the cleavage of PAR-1. The 2.2-A crystal structure reveals a rigid zymogen with unusual features Rsults indicate that plasma levels of Granzyme K could serve as a useful diagnostic marker to stage sepsis, permitting better classification, specific treatments of patients, and may play a functional role in the development of sepsis. GrK not only constitutes a redundant functional backup mechanism that assists GrA-induced cell death but that it also displays a unique function by cleaving its own specific substrates. Gr3 proenzymes is activated by cathepsin C which concomitantly decreased the molecular weight to that of active Gr3. Extracellular GrK is an unexpected direct modulator of lipopolysaccharide-TLR4 signaling during the antimicrobial innate immune response.

Pubmed identfication : 7758581

Qualifiers : classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics

RefSeq identity : NM_002104

Synonyms : TRYP2 PRSS

Synonyms gene name : granzyme K (serine protease, granzyme 3; tryptase II) granzyme K (granzyme 3; tryptase II)

Synonyms name : tryptase II

Tree numbers : E05.196.401.143 E05.301.300.096 E05.478.566.320.200 E05.601.262 E05.601.470.320.200