Anti-H1N1/H5N1/H3N2 nucleocapsid protein, ALEXA Fluor 594

Product name : Anti-H1N1/H5N1/H3N2 nucleocapsid protein, ALEXA Fluor 594

Catalog number : GENTObs-4619R-A594

Supplier : Bioss Polyclonal Antibodies

Price : 489 EUR

Size : 100 microliters

More about:

Concept : Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

Entrez Gene : interferon induced transmembrane protein 3  (IFITM3)

Gene :

Gene ontology - Biological process : immune response response to virus defense response to virus negative regulation of viral entry into host cell response to interferon-beta type I interferon signaling pathway negative regulation of viral genome replication response to interferon-gamma negative regulation of viral transcription response to interferon-alpha

Gene ontology - Cellular component : plasma membrane extracellular exosome lysosomal membrane late endosome membrane integral component of membrane

Gene ontology - Molecular function : protein binding

InterPro : CD225/Dispanin family  (IFITM1)

Long gene name :

Name : Blotting, Western

PubMed : IFITM2 and IFITM3, disrupted early steps (entry and/or uncoating) of the viral infection, viperin, ISG20, and double-stranded-RNA-activated protein kinase, inhibited steps in west nile virus and dengue virus viral proteins and/or RNA biosynthesis. IFITM1, IFITM2, and IFITM3 inhibit HIV-1 replication through interfering with virus entry. Authors show that interferon-induced transmembrane protein 1 (IFITM-1), IFITM-2, and IFITM-3 exhibit a broad spectrum of antiviral activity against several members of the Bunyaviridae family. Incorporation of IFITM1, IFITM2 and IFITM3 into HIV-1 virions impair viral fusion and spread. promoter demethylation enhances transcriptional response to IFN-alpha treatment in melanoma cells IFITM3 protein was highly expressed in invasive breast cancer compared to normal tissues and was significantly associated with estrogen receptor and progesterone receptor status. Exposure of A(H1N1)pdm09-infected epithelial cells to HIV-1 viral particles or its gp120 enhanced by 25% the IFITM3 content. resulting in a decrease in influenza replication. Authors suggest that IFITM3 adopts multiple membrane topologies involving at least one intramembrane domain in its antivirally active conformation. there is one transmembrane helix in the human IFITM3 with a possible role in virus entry cell-extrinsic and cell-intrinsic factors including IFITM3 have roles in regulating the efficiency and kinetics of virus entry and fusion with target cells

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Tree numbers : E05.196.401.143 E05.301.300.096 E05.478.566.320.200 E05.601.262 E05.601.470.320.200