Product name : Anti-H1N1/H5N1/H3N2 nucleocapsid protein, ALEXA Fluor 594
Catalog number : GENTObs-4620R-A594
Supplier : Bioss Polyclonal Antibodies
Price : 489 EUR
Size : 100 microliters
Concept : Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Entrez Gene : interferon induced transmembrane protein 3 (IFITM3)
Gene ontology - Biological process : immune response response to virus defense response to virus negative regulation of viral entry into host cell response to interferon-beta type I interferon signaling pathway negative regulation of viral genome replication response to interferon-gamma negative regulation of viral transcription response to interferon-alpha
Gene ontology - Cellular component : plasma membrane extracellular exosome lysosomal membrane late endosome membrane integral component of membrane
Gene ontology - Molecular function : protein binding
InterPro : CD225/Dispanin family (IFITM1)
Long gene name :
Name : Blotting, Western
PubMed : Vesicular stomatitis virus and influenza A virus increased IFITM3-K88me1 levels by promoting the interaction between IFITM3 and SET7, suggesting that this pathway could be hijacked to support infection; conversely, IFN-alpha reduced IFITM3-K88me1 levels. IFITM2 and IFITM3, disrupted early steps (entry and/or uncoating) of the viral infection, viperin, ISG20, and double-stranded-RNA-activated protein kinase, inhibited steps in west nile virus and dengue virus viral proteins and/or RNA biosynthesis. IFITM1, IFITM2, and IFITM3 inhibit HIV-1 replication through interfering with virus entry. Host IFITM3,IFITM2 and IFITM1 facilitate morphogenesis of the human cytomegalovirus assembly. IFITM3 may redirect IAV fusion to a non-productive pathway, perhaps by promoting fusion with intralumenal vesicles within multivesicular bodies/late endosomes. This meta-analysis suggests that IFITM3 rs12252 T>C polymorphism is significantly associated with increased risk of severe influenza but not with the chance of initial virus infection. A novel association between IFITM3 gene polymorphism and rapid disease progression is reported in an acute HIV-1-infected MSM cohort in China. we demonstrate that the E3 ubiquitin ligase NEDD4 ubiquitinates IFITM3 in cells and in vitro. there is one transmembrane helix in the human IFITM3 with a possible role in virus entry The present study identified the transcripts, which were affected by the downregulation of endogenous IFITM3 and the pathways they were involved in. These findings may lead to an improved understanding of the biological functions of IFITM3.
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Tree numbers : E05.196.401.143 E05.301.300.096 E05.478.566.320.200 E05.601.262 E05.601.470.320.200