Anti- H2AFZ Antibody

Product name : Anti- H2AFZ Antibody

Catalog number : GEN6010378

Supplier : MBS Polyclonals

Price : 603 EUR

Size : 0.2 ml

More about:

Classification : Histones

Concept : Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

Discovery year : 1993-10-28

Entrez Gene : H2A histone family member Z  (H2AFZP6)  (HIST2H2AC)

Entrez gene record : 3015

GenBank acession : X52317

Gene : H2AZ

Gene ontology - Biological process : positive regulation of transcription from RNA polymerase II promoter chromatin silencing cellular response to estradiol stimulus

Gene ontology - Cellular component : nucleus extracellular exosome nuclear euchromatin nuclear heterochromatin nucleosome Barr body

Gene ontology - Molecular function : protein binding RNA polymerase II core promoter sequence-specific DNA binding protein heterodimerization activity RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding nucleosomal DNA binding chromatin DNA binding

Havana BLAST/BLAT : OTTHUMG00000131048

Identity : 4744

InterPro : Histone H2A/H2B/H3  (HIST2H2AC)  (HIST2H2BE) Histone-fold  (CHRAC1) Histone H2A conserved site  (HIST2H2AC) Histone H2A, C-terminal domain  (HIST2H2AC) Histone H2A  (HIST2H2AC)  (HIST3H2A)

Kegg : Alcoholism - Homo sapiens (human) Systemic lupus erythematosus - Homo sapiens (human)

Locus : 4q23

Long gene name : symbol withdrawn, see H2AFZ

Name : Blotting, Western

PubMed : incorporation of the histone variant H2A.Z at the promoter regions of PPARgamma target genes by p400/Brd8 is essential to allow fat cell differentiation identify the essential histone variant H2A.Z as a new structural component of the centromere The nucleosome destabilizing effect of H2A.Z acetylation takes place synergistically with the acetylation of the rest of the core histones. This review provides a brief overview of H2A.Z biology and presents hypotheses that could reconcile contradictory reports that are found in the literature regarding the influence of H2A.Z on nucleosome stability. acetylation of H2A.Z is a key modification associated with gene activity in normal cells and epigenetic gene deregulation in tumorigenesis. The short forms of H2A.Z in both yeast and human cells are more loosely associated with chromatin than the full-length proteins, indicating a conserved function for the H2A.Z C-terminal tail in regulating the association of H2A.Z with nucleosomes. H2A.Z exchange promotes specific patterns of histone modification and reorganization of the chromatin architecture, leading to the assembly of a chromatin template that is an efficient substrate for the DNA double-strand break repair machinery. A mutational analysis revealed that the amino-acid difference at position 38 is at least partially responsible for the structural polymorphism in the L1 loop region of H2A.Z.1 and H2A.Z.2. the predictive values regarding low expressions of H2AFZ and CASP8AP2 and high white blood cell count suggest that these features could help to identify more accurately patients at greater risk of relapse. Results suggest that the N-terminal tail of H2A.Z makes distinctively different contributions to epigenetic events.

Pubmed identfication : 1697587

Qualifiers : classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics

RefSeq identity : NM_002106

Synonyms : H2A.Z

Synonyms gene : H2AZ

Synonyms gene name : H2A histone family, member Z

Tree numbers : E05.196.401.143 E05.301.300.096 E05.478.566.320.200 E05.601.262 E05.601.470.320.200

WikiPathWays : Retinoblastoma (RB) in Cancer Proteasome Degradation