Anti- H3-K14 Antibody

Product name : Anti- H3-K14 Antibody

Catalog number : GEN9125151

Supplier : MBS Polyclonals

Price : 343 EUR

Size : 50ug

More about:

Classification : Histones

Concept : Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

Discovery year : 1998-08-27

Entrez Gene : keratin 14

Entrez gene record : 8354

GenBank acession : X83550

Gene : HIST1H3I

Gene ontology - Biological process : aging response to ionizing radiation epidermis development keratinization cornification response to zinc ion hemidesmosome assembly intermediate filament bundle assembly hair cycle

Gene ontology - Cellular component : nucleus cytoplasm cytosol extracellular exosome basal part of cell keratin filament intermediate filament cell periphery

Gene ontology - Molecular function : protein binding structural constituent of cytoskeleton keratin filament binding

Havana BLAST/BLAT : OTTHUMG00000016184

Identity : 4771

InterPro : Intermediate filament protein  (SYNC) Intermediate filament protein, conserved site Keratin, type I  (KRT33B) Prefoldin  (PFDN2)

Locus : 6p22.1

Long gene name : histone cluster 1 H3 family member i

Name : Blotting, Western

PubMed : Observational study of gene-disease association. (HuGE Navigator) Immunocytochemistry using this antibody cocktail comprises five antibodies recognising p63, and cytokeratins ( 7, 18, 5 and 14) showed good sensitivity and specificity for diagnosing breast cancers. Thus, this method is useful for mammary cytology using FNA investigated novel KRT14 missense mutations in epidermolysis bullosa simplex in a cellular expression system in order to analyse their effects on the keratin cytoskeleton Naegeli-Franceschetti-Jadassohn syndrome results from haploinsufficiency for K14 and increased susceptibility of keratinocytes to pro-apoptotic signals may be involved in the pathogenesis of this ectodermal dysplasia syndrome heterozygous G to A transition was found at nucleotide postion 1231 in exon 6 of KRT14 in family with epidermolysis bullosa simplex, generalized Two missense mutations identified are in highly conserved regions of KRT14 and KRT5 for epidermolysis bullosa simplex. investigated a family in which 1 of 3 children was diagnosed with a localized form of epidermolysis bullosa simplex and there was no family history of blistering; results argue against parental somatic and germline mosaicism in the family and suggest the novel p.Val270Ala mutation in KRT14 also represents a de novo event which occurred in the proband in silico analysis of all epidermolysis bullosa simplex causing point mutations on the 2B domain of K5 and K14; result showed all pathogenic point mutations exert their dominant negative effect on the K5/K14 coiled-coil heterodimer complex by altering interchain interaction,leading to changes in stability and assembly competence of the heterodimer complex The present study confirmed that CK14, but not CK20 or CK7, is expressed in urothelial carcinoma with squamous differentiation and squamous cell carcinoma of the urinary bladder. We concluded that smoking habits were capable of inducing changes in global DNA methylation, miR-9-3 methylation status and K19 expression.

Pubmed identfication : 9031620 9439656 12408966

Qualifiers : classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics

RefSeq identity : NM_003533

Synonyms : H3/f H3.f

Synonyms gene : H3FF

Synonyms gene name : H3 histone family, member F histone 1, H3i histone cluster 1, H3i

Tree numbers : E05.196.401.143 E05.301.300.096 E05.478.566.320.200 E05.601.262 E05.601.470.320.200

WikiPathWays : Corticotropin-releasing hormone signaling pathway