anti-H3F3A Antibody

Product name : anti-H3F3A Antibody

Catalog number : 31-007

Supplier : proscience

Price : 180 EUR

Size : 100 ug

More about:

Classification : Histones

Concept : Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

Discovery year : 1989-12-11

Entrez Gene : H3 histone family member 3A  (H3F3AP2)

Entrez gene record : 3020

GenBank acession : BC029405

Gene : H3F3A

Gene ontology - Biological process : positive regulation of cell growth cell proliferation chromatin silencing at rDNA osteoblast differentiation nucleosome assembly single fertilization embryo implantation nucleus organization muscle cell differentiation telomere organization

Gene ontology - Cellular component : nucleus extracellular region nucleoplasm extracellular exosome protein complex nuclear chromosome, telomeric region nuclear chromosome nucleosome nuclear nucleosome Barr body

Gene ontology - Molecular function : protein binding RNA polymerase II core promoter sequence-specific DNA binding protein heterodimerization activity histone binding RNA polymerase II distal enhancer sequence-specific DNA binding nucleosomal DNA binding

Havana BLAST/BLAT : OTTHUMG00000037507

Identity : 4764

InterPro : Histone H2A/H2B/H3  (HIST2H2AC)  (HIST2H2BE) Histone-fold  (CHRAC1) Histone H3/CENP-A  (CENPA)

Kegg : Transcriptional misregulation in cancer - Homo sapiens (human) Alcoholism - Homo sapiens (human) Systemic lupus erythematosus - Homo sapiens (human)

Locus : 1q42.12

Long gene name : H3 histone family member 3A

Name : Blotting, Western

PubMed : The mutually exclusive associations of HDAC1/p300, p300/histone, and HDAC1/histone on chromatin contribute to the dynamic regulation of histone acetylation. Data reveal that TPA activates transcription of TBX2 through activating MSK1, which leads to an increase in phosphorylated histone H3 and the recruitment of Sp1 to the TBX2 gene. The kinase activity of Aurora B on serine 31 of histone H3.3 was biochemically confirmed with nucleosomal substrates in vitro. A remarkable picture of tumor type specificity for histone H3.3 driver alterations emerges, indicating that histone H3.3 residues, mutations and genes have distinct functions. Part of multiple H3.3-specific histone chaperone complexes recurrent mutations in a regulatory histone in humans; data suggest that defects of the chromatin architecture underlie paediatric and young adult GBM pathogenesis diffuse intrinsic pontine gliomas containing K27M mutation display lower overall amounts of H3 with trimethylated lysine 27(H3K27me3);H3K27M inhibits enzymatic activity of Polycomb repressive complex 2 through interaction with the EZH2 subunit; propose a model where aberrant epigenetic silencing through H3K27M-mediated inhibition of PRC2 activity promotes gliomagenesis H3F3A exon 2 mutation analyzed in solid tumors from 1351 South Korean patients Loss of H3.3 from pericentromeric heterochromatin upon DAXX or PML depletion suggests that the targeting of H3.3 to PML-NBs is implicated in pericentromeric heterochromatin organization. All reported H3.3 mutations identified in human tumors have been in the H3F3A gene leading to single codon changes within the N-terminal tail of the H3.3 protein. [Review]

Pubmed identfication : 3031613

Qualifiers : classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics

RefSeq identity : NM_002107

Synonyms : H3.3A

Synonyms gene : H3F3

Synonyms gene name : H3 histone, family 3A

Tree numbers : E05.196.401.143 E05.301.300.096 E05.478.566.320.200 E05.601.262 E05.601.470.320.200

WikiPathWays : Histone Modifications Gastric Cancer Network 1