Anti- HADHA Antibody

Product name : Anti- HADHA Antibody

Catalog number : GEN2523699

Supplier : MBS Polyclonals

Price : 348 EUR

Size : 0.12 ml

More about:

Concept : Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

Discovery year : 1994-12-16

Entrez Gene : hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit  (HADHAP2)

Entrez gene record : 3030

GenBank acession : D16480

Gene : HADHA

Gene ontology - Biological process : response to insulin response to drug fatty acid beta-oxidation cardiolipin acyl-chain remodeling

Gene ontology - Cellular component : extracellular matrix mitochondrion mitochondrial inner membrane mitochondrial nucleoid mitochondrial fatty acid beta-oxidation multienzyme complex

Gene ontology - Molecular function : protein binding protein complex binding NAD binding 3-hydroxyacyl-CoA dehydrogenase activity long-chain-enoyl-CoA hydratase activity acetyl-CoA C-acetyltransferase activity enoyl-CoA hydratase activity fatty-acyl-CoA binding long-chain-3-hydroxyacyl-CoA dehydrogenase activity

Havana BLAST/BLAT : OTTHUMG00000096979

Identity : 4801

InterPro : NAD(P)-binding domain  (HMGA1P8) 3-hydroxyacyl-CoA dehydrogenase, conserved site 3-hydroxyacyl-CoA dehydrogenase, C-terminal 6-phosphogluconate dehydrogenase C-terminal domain-like 3-hydroxyacyl-CoA dehydrogenase, NAD binding 6-phosphogluconate dehydrogenase, domain 2 Crotonase superfamily Enoyl-CoA hydratase/isomerase, conserved site ClpP/crotonase-like domain Fatty acid oxidation complex, alpha subunit, mitochondrial

Kegg : Lysine degradation - Homo sapiens (human) Fatty acid degradation - Homo sapiens (human) Valine, leucine and isoleucine degradation - Homo sapiens (human) Tryptophan metabolism - Homo sapiens (human) beta-Alanine metabolism - Homo sapiens (human) Butanoate metabolism - Homo sapiens (human) Propanoate metabolism - Homo sapiens (human) Biosynthesis of unsaturated fatty acids - Homo sapiens (human) Fatty acid elongation - Homo sapiens (human)

Locus : 2p23.3

Locus Specific Databases : LRG_747

Long gene name : hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha

Name : Blotting, Western

PubMed : Observational study of gene-disease association. (HuGE Navigator) Results emphasize the value of cDNA analysis in the characterization of HADHA and HADHB mutations and further strengthen the model of haploinsufficiency as a major pathomechanism in MTP defects. TP-alpha, collagen alpha-1(VI) chain and S100A9 are potential biomarkers of esophageal squamous cell carcinoma, and may play an important role in tumorigenesis and development of ESCC. Plasma concentration varied more than erythrocyte levels. Postprandial period and fasting. Neither maternal nor fetal heterozygosity for the E474Q mutation is a relevant factor of HELLP syndrome. There might be diverse etiological factors in China contributing to AFLP other than the frequently reported mutation in the LCHAD. Report probable Kashubian origin of the prevalent HADHA c.1528G>C mutation responsible for long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency in Poland. Both children were homozygous for the common mutation c.1528G>C and the parents were heterozygous for this same mutation. High HADHA protein expression is associated with response to platinum-based chemotherapy for lung cancer. revealed a novel G/A allelic change in the intronic region [chromosomal position 26417674; 20 bp adjacent to an already published SNP (rs151243950)] for one among the three acute fatty liver of pregnancy patients

Pubmed identfication : 9605857 7918661

Qualifiers : classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics

RefSeq identity : NM_000182


Synonyms gene name : hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit

Synonyms name : gastrin-binding protein long-chain-3-hydroxyacyl-CoA dehydrogenase long-chain 2-enoyl-CoA hydratase mitochondrial trifunctional protein, alpha subunit

Tree numbers : E05.196.401.143 E05.301.300.096 E05.478.566.320.200 E05.601.262 E05.601.470.320.200

WikiPathWays : Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways Fatty Acid Beta Oxidation Mitochondrial LC-Fatty Acid Beta-Oxidation Valproic acid pathway