Anti- HAGH Antibody

Product name : Anti- HAGH Antibody

Catalog number : GEN9126023

Supplier : MBS Polyclonals

Price : 558 EUR

Size : 0.2 mg

More about:

Concept : Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

Discovery year : 2001-06-22

Entrez Gene : hydroxyacylglutathione hydrolase  (HAGHL)

Entrez gene record : 3029

GenBank acession : X90999

Gene : HAGH

Gene ontology - Biological process : pyruvate metabolic process glutathione biosynthetic process methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

Gene ontology - Cellular component : cytosol extracellular exosome mitochondrial matrix

Gene ontology - Molecular function : protein binding metal ion binding hydroxyacylglutathione hydrolase activity

Havana BLAST/BLAT : OTTHUMG00000128662

Identity : 4805

InterPro : Metallo-beta-lactamase  (MBLAC2) Hydroxyacylglutathione hydrolase, C-terminal domain Hydroxyacylglutathione hydrolase  (HAGHL)

Kegg : Pyruvate metabolism - Homo sapiens (human)

Locus : 16p13.3

Long gene name : hydroxyacylglutathione hydrolase

Name : Blotting, Western

PubMed : Observational study of gene-disease association. (HuGE Navigator) Observational study of gene-disease association. (HuGE Navigator) Data show that the GLX2 gene, which encodes glyoxalase II enzyme, is up-regulated by p63 and p73. Overexpression of glyoxalase II is associated with kidney tumor In androgen-dependent prostate cancer cells, testosterone upregulates GLO2 mRNA levels. In androgen-independent prostate cancer cells, it downregulates GLO2 mRNA. Human glyoxalase II contains an Fe(II)Zn(II) center but is active as a mononuclear Zn(II) enzyme No association between genetic variants of the HAGH gene and autism spectrum disorder was found. This study suggested that HAGH, rs11859266 and rs3743852 showed significant associations with schizophrenia in males at allelic and genotype levels. Studies indicate that the most extensively investigated The most extensively investigated glyoxalase enzymes are glyoxalase I and glyoxalase II (Glo1 and Glo2). This article reports for the first time a possible additional role of Glo2 that, after interacting with a target protein, is able to promote S-glutathionylation.

Pubmed identfication : 3025077 7327557

Qualifiers : classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics

RefSeq identity : NM_005326

Synonyms : GLO2 GLXII HAGH1

Synonyms gene name : hydroxyacyl glutathione hydrolase

Tree numbers : E05.196.401.143 E05.301.300.096 E05.478.566.320.200 E05.601.262 E05.601.470.320.200