Anti- Hamartin/TSC1 Antibody

Product name : Anti- Hamartin/TSC1 Antibody

Catalog number : GEN8501424

Supplier : MBS Polyclonals

Price : 393 EUR

Size : 100ug

More about:

Classification : TSC complex

Concept : Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

Discovery year : 1986-01-01

Entrez Gene : TSC complex subunit 1  (TESC)  (TSC1)

GenBank acession : AF013168

Gene : TSC1

Gene ontology - Biological process : cell-matrix adhesion negative regulation of cell proliferation protein stabilization regulation of translation cell projection organization negative regulation of neuron projection development regulation of protein kinase activity myelination negative regulation of GTPase activity memory T cell differentiation

Gene ontology - Cellular component : nucleus cytoplasm cytosol plasma membrane protein complex membrane perinuclear region of cytoplasm lipid droplet growth cone TSC1-TSC2 complex

Gene ontology - Molecular function : protein binding protein N-terminus binding chaperone binding GTPase activating protein binding

Havana BLAST/BLAT : OTTHUMG00000020844

Identity : 12362

InterPro : Armadillo-type fold Hamartin  (TSC1)

Kegg : mTOR signaling pathway - Homo sapiens (human) PI3K-Akt signaling pathway - Homo sapiens (human) AMPK signaling pathway - Homo sapiens (human) Longevity regulating pathway - Homo sapiens (human) Insulin signaling pathway - Homo sapiens (human) Choline metabolism in cancer - Homo sapiens (human) Phospholipase D signaling pathway - Homo sapiens (human)

Locus : 9q34

Locus Specific Databases : TSC Mutation Database Tuberous sclerosis database LRG_486

Long gene name : TSC complex subunit 1

Name : Blotting, Western

PubMed : Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) AKT3 has a role in prostate cancer proliferation through regulation of Akt, B-Raf, and TSC1/TSC2 Target of Rapamycin 1 causes neurons to have multiple axons and the translation of SAD kinase increases as well the TSC/mTOR/HIF axis is activated by the KSHV vGPCR in Kaposi's sarcoma, which amplifies the angiogenic signal Haploinsufficiency for TSC1 can contribute to the development of bladder cancer and, if this is so, the LOH of TSC1 observed in >50% of transitional cell carcinomas is biologically significant. During conditions of cell stress, GADD34 forms a stable complex with tuberous sclerosis complex (TSC) 1/2, causes TSC2 dephosphorylation, and inhibits signaling by mammalian target of the rapamycin (mTOR). hamartin binds to NADE to regulate neuronal cell function and loss of this association is likely to contribute to the brain pathology in tuberous sclerosis complex mineralized focal cortical dysplasias with balloon cells revealed an increased frequency of TSC2 allelic variants but not TSC1 The TSC1-TSC2-TBC1D7 (TSC-TBC) complex is the functional complex that senses specific cellular growth conditions and possesses Rheb-GAP activity. brain somatic mutations in TSC1 and TSC2 cause focal cortical dysplasia

Pubmed identfication : 9242607 10806479

Qualifiers : classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics

Synonyms : KIAA0243 LAM hamartin

Synonyms gene : TSC

Synonyms gene name : tuberous sclerosis 1

Synonyms name : hamartin

Tree numbers : E05.196.401.143 E05.301.300.096 E05.478.566.320.200 E05.601.262 E05.601.470.320.200

WikiPathWays : AMP-activated Protein Kinase (AMPK) Signaling Angiopoietin Like Protein 8 Regulatory Pathway Insulin Signaling Signaling Pathways in Glioblastoma Integrated Breast Cancer Pathway Target Of Rapamycin (TOR) Signaling BDNF-TrkB Signaling 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression Polycystic Kidney Disease Pathway Nanoparticle triggered autophagic cell death