Anti- HMGA1 Antibody

Product name : Anti- HMGA1 Antibody

Catalog number : GEN8500565

Supplier : MBS Polyclonals

Price : 393 EUR

Size : 100ug

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Classification : Transcribed pseudogenes with published function

Concept : Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

Discovery year : 2010-11-17

Entrez Gene : high mobility group AT-hook 1  (HMGA1P6)  (NBN)

Entrez gene record : 100130009

Gene : HMGA1P8

Gene ontology - Biological process : positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of cell proliferation response to virus protein complex assembly positive regulation of cellular senescence base-excision repair nucleosome disassembly establishment of integrated proviral latency nuclear transport

Gene ontology - Cellular component : nucleus cytosol focal adhesion nucleoplasm transcription factor complex RNA polymerase II transcription factor complex senescence-associated heterochromatin focus

Gene ontology - Molecular function : protein binding ligand-dependent nuclear receptor transcription coactivator activity chromatin binding transcription factor activity, sequence-specific DNA binding enzyme binding retinoid X receptor binding AT DNA binding retinoic acid receptor binding enhancer sequence-specific DNA binding DNA-(apurinic or apyrimidinic site) lyase activity

Havana BLAST/BLAT : OTTHUMG00000152827

Identity : 39183

InterPro : AT hook, DNA-binding motif  (AHDC1)  (HLA-DOA) HMG-I/HMG-Y, DNA-binding, conserved site  (DFNY1)  (FABP6)  (HLA-DOA) High mobility group protein HMGA1, mammal  (HMGA1) High mobility group protein HMGA

Locus : 2p13.1

Long gene name : high mobility group AT-hook 1 pseudogene 8

Name : Blotting, Western

PubMed : Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) HMGA1 positively regulates the human KL promoter in breast and ovarian cancer cells HMGA1 repression by RNA interference reduced neuroblastoma cell proliferation, indicating that HMGA1 is a novel MYCN target gene relevant for neuroblastoma tumorigenesis. HMGA proteins are overexpressed in different tumors and the HMGA genes are often involved in chromosomal rearrangements [review] an increased CCNB2 expression in human pituitary adenomas of different histotypes that is directly correlated with HMGA1 and HMGA2 expression. Study suggests a novel mechanism, based on Bcl-2 induction, by which HMGA1 overexpression contributes to the escape from apoptosis leading to neoplastic transformation. miR-296 regulates HMGA1 expression and is associated with prostate cancer growth and invasion HMGA1 transcription activity can dependent and independent of 7SK snRNA. HMGA1B mediates PIT1 over expression in pituitary neoplasms. in splenic hemangioma with t(3;6)(q26;p21), the entire coding region of HMGA1 comes under the control of the TBL1XR1 promoter, bringing about dysregulation of HMGA1

Pubmed identfication : 12727900 20975707

Qualifiers : classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics

RefSeq identity : NG_032791

Synonyms : HMGA1-p

Tree numbers : E05.196.401.143 E05.301.300.096 E05.478.566.320.200 E05.601.262 E05.601.470.320.200

WikiPathWays : Senescence and Autophagy in Cancer miR-targeted genes in lymphocytes - TarBase miR-targeted genes in muscle cell - TarBase miR-targeted genes in leukocytes - TarBase Adipogenesis miR-targeted genes in squamous cell - TarBase Preimplantation Embryo