Anti- HMGA2 Antibody

Product name : Anti- HMGA2 Antibody

Catalog number : GEN2516816

Supplier : MBS Polyclonals

Price : 348 EUR

Size : 0.12 ml

More about:

Classification : Canonical high mobility group

Concept : Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

Discovery year : 1998-10-23

Entrez Gene : high mobility group AT-hook 2  (HMGA1P2)  (NBN)

Entrez gene record : 8091

GenBank acession : U28754

Gene : HMGA2

Gene ontology - Biological process : positive regulation of transcription, DNA-templated negative regulation of apoptotic process multicellular organism development fat cell differentiation positive regulation of cell cycle arrest mesodermal cell differentiation epithelial to mesenchymal transition negative regulation of single stranded viral RNA replication via double stranded DNA intermediate mesodermal-endodermal cell signaling chromosome breakage

Gene ontology - Cellular component : nucleus nucleoplasm protein-DNA complex nuclear chromosome SMAD protein complex senescence-associated heterochromatin focus

Gene ontology - Molecular function : DNA binding transcription factor activity, transcription factor binding nucleosomal DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding, bending SMAD binding AT DNA binding DNA-(apurinic or apyrimidinic site) lyase activity MH2 domain binding MH1 domain binding

Havana BLAST/BLAT : OTTHUMG00000168936

Identity : 5009

InterPro : AT hook, DNA-binding motif  (AHDC1)  (HLA-DOA) HMG-I/HMG-Y, DNA-binding, conserved site  (DFNY1)  (FABP6)  (HLA-DOA) High mobility group protein HMGA

Kegg : Transcriptional misregulation in cancer - Homo sapiens (human) MicroRNAs in cancer - Homo sapiens (human)

Locus : 12q14.3

Long gene name : high mobility group AT-hook 2

Name : Blotting, Western

PubMed : HMGA2 promoter is coregulated by a polymorphic dinucleotide (TC)-repeat Ectopic expression of let-7 miRNA reduced HMGA2 and cell proliferation in a lung cancer cell. High expression of HMGA2 in gastric cancer correlates with tumor invasiveness and is an independent prognostic factor. Importance of HMGA2 in reversibly maintaining mitotic activities and epithelial-mesenchymal transition suggests importance as a potential target in pancreatic cancer. HMGA2 overexpression in acute aortic dissection occurs in a let-7d-independent manner and is associated with EndMT of the vasa vasorum. Heterogeneous 3' UTR lengths render HMGA2 susceptible to different levels of negative regulation by microRNAs, which represents an important mechanism of HMGA2 reactivation in serous ovarian cancer. Expression of HMGA2, loss of E-cadherin and expression of vimentin may indicate high degree malignancy of bladder cancer. HMGA2 promotes tongue squamous cell carcinoma invasion and metastasis. our data indicated that HMGA2 was associated with apoptosis, migration and invasion of prostate cancer, which might be a promising therapeutic target for prostate cancer. High HMGA2 expression was related to lymph node metastasis and poor prognosis in ESCC. Our results indicated that HMGA2 could act as a potential biomarker for prognosis evaluation of ESCC patients.

Pubmed identfication : 8824803 9003504

Qualifiers : classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics

RefSeq identity : NM_003483

Synonyms : BABL LIPO

Synonyms gene : HMGIC

Synonyms gene name : high-mobility group (nonhistone chromosomal) protein isoform I-C

Tree numbers : E05.196.401.143 E05.301.300.096 E05.478.566.320.200 E05.601.262 E05.601.470.320.200

WikiPathWays : Mesodermal Commitment Pathway