Anti- HMGB1 Antibody

Product name : Anti- HMGB1 Antibody

Catalog number : GEN6002291

Supplier : MBS Polyclonals

Price : 597 EUR

Size : 0.2 ml

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Classification : Canonical high mobility group

Concept : Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

Discovery year : 1993-12-13

Entrez Gene : high mobility group box 1  (HMGB1)

Entrez gene record : 3146

GenBank acession : D63874

Gene : HMGB1

Gene ontology - Biological process : positive regulation of ERK1 and ERK2 cascade toll-like receptor signaling pathway positive regulation of interferon-beta production positive regulation of DNA binding positive regulation of sprouting angiogenesis positive regulation of dendritic cell differentiation DNA topological change T-helper 1 cell activation T-helper 1 cell differentiation regulation of nucleotide-excision repair

Gene ontology - Cellular component : nucleus plasma membrane extracellular region nucleoplasm cell surface neuron projection early endosome secretory granule lumen ficolin-1-rich granule lumen condensed chromosome

Gene ontology - Molecular function : cytokine activity single-stranded RNA binding double-stranded DNA binding lyase activity damaged DNA binding C-X-C chemokine binding bubble DNA binding calcium-dependent protein kinase regulator activity DNA polymerase binding supercoiled DNA binding

Havana BLAST/BLAT : OTTHUMG00000016670

Identity : 4983

InterPro : High mobility group box domain  (HMG20A) High mobility group protein HMGB1  (HMGB1) HMG box A DNA-binding domain, conserved site  (HLA-DOA)

Kegg : Base excision repair - Homo sapiens (human)

Locus : 13q12.3

Long gene name : high mobility group box 1

Name : Blotting, Western

PubMed : HMGB1 plays an important role in Gram-negative sepsis by catalyzing movement of LPS monomers from LPS aggregates to CD14 to initiate a TLR4-mediated proinflammatory response Study results are consistent with the hypothesis that decreased cholinergic anti-inflammatory pathway activity is associated with increased HMGB1 blood levels in patients with rheumatoid arthritis. These findings indicate that tissue hypoxia and its resultant extracellular HMGB-1 might play an important role in the development of arthritis. Data support a potential role for HMGB1 as a biomarker and diagnostic tool for the differential diagnosis of asthma and COPD. findings indicate that platelets represent a source of HMGB1, an ancestral signal of necrosis, in the vasculature of systemic sclerosis patients, possibly contributing to persistent microvascular injury and endothelial cell activation [review] As results of these studies showed, the extent and kinetics of HMGB1 release from necrotic cells varies markedly depending on its induction. Lower HMGB1 expression, impaired proliferation and slightly altered fusion capacity in the primary cell cultures. these findings indicated that HMGB1 promoted hepatocellular carcinoma progression partly by enhancing the ERK1/2 and NF-kappaB pathways, upregulating MMP-2, and downregulating p21 via an ERK/c-Myc pathway HMGB1 and IL-33 could play a significant role in the atopic dermatitis pathophysiology due to negative regulation of structural proteins, stratum corneum formation and epidermal growth. The results demonstrated reduction of cell viability upon increasing irinotecan concentration, up-regulated high-mobility group protein B1 gene expression, and down-regulated MMP9 mRNA.

Pubmed identfication : 8661151 11279268

Qualifiers : classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics

RefSeq identity : NM_002128

Synonyms : HMG3 SBP-1 DKFZp686A04236

Synonyms gene : HMG1

Synonyms gene name : high-mobility group (nonhistone chromosomal) protein 1 high-mobility group box 1

Synonyms name : high mobility group box 1 Sulfoglucuronyl carbohydrate binding protein Amphoterin high mobility group protein 1

Tree numbers : E05.196.401.143 E05.301.300.096 E05.478.566.320.200 E05.601.262 E05.601.470.320.200

WikiPathWays : Retinoblastoma (RB) in Cancer DNA Damage Response (only ATM dependent)