anti-HMGB2 / HMG2 Antibody

Product name : anti-HMGB2 / HMG2 Antibody

Catalog number : AM20899PU-N

Supplier : acr

Price : 819 EUR

Size : 50 Вµg

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Classification : Canonical high mobility group

Concept : Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

Discovery year : 1993-12-13

Entrez Gene : high mobility group box 2  (HMGB2)

Entrez gene record : 3148

Gene : HMGB2

Gene ontology - Biological process : male gonad development negative regulation of transcription, DNA-templated inflammatory response spermatogenesis regulation of transcription from RNA polymerase II promoter innate immune response response to lipopolysaccharide defense response to Gram-negative bacterium positive regulation of interferon-beta production positive regulation of erythrocyte differentiation

Gene ontology - Cellular component : extracellular space nucleus cytoplasm extracellular region protein complex nuclear chromatin nucleolus perinuclear region of cytoplasm condensed chromosome cell

Gene ontology - Molecular function : DNA binding transcription regulatory region DNA binding RNA binding protein domain specific binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding damaged DNA binding DNA binding, bending RAGE receptor binding enhancer sequence-specific DNA binding

Havana BLAST/BLAT : OTTHUMG00000160799

Identity : 5000

InterPro : High mobility group box domain  (HMG20A) HMG box A DNA-binding domain, conserved site  (HLA-DOA) High mobility group protein HMGB2  (HMGB2)

Locus : 4q34.1

Long gene name : high mobility group box 2

Name : Blotting, Western

PubMed : In human and murine cartilage, there is an aging-related loss of HMGB2 expression, ultimately leading to its complete absence. The age-related loss of HMGB2 in articular cartilage may represent a mechanism responsible for the decline in adult cartilage stem cell populations. Lrp1-antisense directly binds to high-mobility group box 2 (Hmgb2) and inhibits the activity of Hmgb2 to enhance Srebp1a-dependent transcription of Lrp1. data demonstrate a reciprocal relationship between Hmgb2 and Ctcf in controlling aspects of chromatin structure and gene expression. High levels of HMGB2 directly correlate with the extent of neoplastic changes in cutaneous squamous cell carcinoma. HMGB2 is an effective stimulus for cell differentiation, tumor progression, & metastatic invasion. Increased HMGB2 expression is associated with squamous cell carcinoma of skin. an interaction between HMGB2 and the Wnt/beta-catenin pathway regulates the maintenance of the superficial zone high-mobility group box (HMGB) proteins function as universal sentinels for nucleic acids Data show that Hmgb1 and Hmgb2 function redundantly to enhance Wnt signaling in embryos, and further suggest that integrating Wnt, Shh, and BMP signaling regulates the development of digit5 in forelimbs. Oct4 post-translational modifications (PTMs) form a positive feedback loop, which promotes Akt activation and interaction with Hmgb2 and the SET complex.

Pubmed identfication : 1754403

Qualifiers : classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics

RefSeq identity : NM_001130688

Synonyms gene : HMG2

Synonyms gene name : high-mobility group (nonhistone chromosomal) protein 2 high-mobility group box 2

Tree numbers : E05.196.401.143 E05.301.300.096 E05.478.566.320.200 E05.601.262 E05.601.470.320.200

WikiPathWays : Androgen Receptor Signaling Pathway