Product name : Anti- GZMA Antibody
Catalog number : GEN2526738
Supplier : MBS Polyclonals
Price : 265 EUR
Size : 0.06 ml
Concept : Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Discovery year : 1988-05-31
Entrez Gene : granzyme A (GZMAP1)
Entrez gene record : 3001
Gene : HFSP
Gene ontology - Biological process : apoptotic process immune response cytolysis positive regulation of apoptotic process proteolysis involved in cellular protein catabolic process negative regulation of DNA binding negative regulation of oxidoreductase activity negative regulation of endodeoxyribonuclease activity
Gene ontology - Cellular component : nucleus extracellular region immunological synapse
Gene ontology - Molecular function : serine-type endopeptidase activity protein binding protein homodimerization activity
Havana BLAST/BLAT : OTTHUMG00000097011
Identity : 4891
InterPro : Peptidase S1, PA clan Serine proteases, trypsin family, serine active site Serine proteases, trypsin family, histidine active site Peptidase S1A, chymotrypsin family Serine proteases, trypsin domain
Kegg : Neuroactive ligand-receptor interaction - Homo sapiens (human)
Locus : 5q11.2
Long gene name : granzyme A
Name : Blotting, Western
PubMed : A critical and previously unsuspected role is revealed for granzymes A and B in dictating immunogenicity by influencing the mode of tumor cell death. HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A. Data indicate N-terminomics on the human and mouse granzymes A and K by combined fractional diagonal chromatography (COFRADIC). The exocytosed granzyme A enters target cells and mediates IL-1beta maturation independently of caspase-1 and without inducing cytotoxicity. GrK not only constitutes a redundant functional backup mechanism that assists GrA-induced cell death but that it also displays a unique function by cleaving its own specific substrates. Taken together, the authors verified that histone H3 is a real substrate for GzmA in vivo in the Raji cells treated by staurosporin. GrA expression is increased in type II pneumocytes of patients with very severe COPD. These results indicate that GrA may be important in the development of COPD. Granzyme A is a proinflammatory protease. We herewith identify GZMA as critical effector molecule of human Treg function for gastrointestinal immune response in an experimental GvHD model. Our results suggest that granzyme A could be considered another biomarker of TB, that can be used, other than IFN-gamma, to discriminate between patients with active TB and LTBI subjects
Pubmed identfication : 3262682 3533635
Qualifiers : classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics
RefSeq identity : NM_006144
Synonyms : GZMA
Synonyms gene : CTLA3
Synonyms gene name : granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
Synonyms name : CTL tryptase Cytotoxic T-lymphocyte-associated serine esterase-3 Hanukah factor serine protease) granzyme 1
Tree numbers : E05.196.401.143 E05.301.300.096 E05.478.566.320.200 E05.601.262 E05.601.470.320.200
