Product name : Anti- H2AFY Antibody
Catalog number : GEN9125711
Supplier : MBS Polyclonals
Price : 558 EUR
Size : 0.2 mg
Classification : Histones
Concept : Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Discovery year : 1999-07-22
Entrez Gene : H2A histone family member Y (H2AFY) (HIST2H2AC)
Entrez gene record : 9555
GenBank acession : AF054174
Gene : H2AFY
Gene ontology - Biological process : negative regulation of transcription from RNA polymerase II promoter regulation of lipid metabolic process negative regulation of histone H3-K4 methylation negative regulation of gene expression, epigenetic positive regulation of keratinocyte differentiation regulation of response to oxidative stress positive regulation of maintenance of mitotic sister chromatid cohesion negative regulation of protein serine/threonine kinase activity negative regulation of histone phosphorylation negative regulation of protein localization to chromosome, telomeric region
Gene ontology - Cellular component : nucleus extracellular exosome nuclear chromatin ESC/E(Z) complex pericentric heterochromatin nuclear chromosome condensed chromosome nucleosome sex chromatin Barr body
Gene ontology - Molecular function : protein binding RNA polymerase II regulatory region sequence-specific DNA binding DNA binding protein heterodimerization activity core promoter sequence-specific DNA binding protein kinase binding nucleosomal DNA binding enzyme binding rDNA binding protein serine/threonine kinase inhibitor activity
Havana BLAST/BLAT : OTTHUMG00000129141
Identity : 4740
InterPro : Histone H2A/H2B/H3 (HIST2H2AC) (HIST2H2BE) Histone-fold (CHRAC1) Histone H2A, C-terminal domain (HIST2H2AC) Histone H2A (HIST2H2AC) (HIST3H2A) Macro domain (MACROD1) Core histone macro-H2A (HIST2H2AC)
Kegg : Alcoholism - Homo sapiens (human) Systemic lupus erythematosus - Homo sapiens (human)
Locus : 5q31.1
Long gene name : H2A histone family member Y
Name : Blotting, Western
PubMed : Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) We show that composite nucleosomes containing mH2A and NRF-1 are stably positioned on gene regulatory regions and can buffer transcriptional noise associated with antiviral responses The Skp2-mH2A1-CDK8 axis has a critical role in breast cancer development via dysregulation of the G2/M transition, polyploidy, cell growth dysregulation, and loss of tumor suppression. significant inverse correlation between mH2A and CDK8 expression levels exists in melanoma patient samples expression of histone macroH2A1.1 and macroH2A2 predicts lung cancer recurrence. direct interaction and binding features between VRK1 and macroH2A1.2 distributed during the maintainance phase of x inactivation throughout cell cycle an unexpected role for macroH2A1 in the escape from heterochromatin-associated silencing and the enhancement of autosomal gene transcription macroH2A1.1 expression correlates with poor survival of triple-negative breast cancer patients High MacroH2A1 expression is associated with epigenetic markers for activation of lipogenic genes in fat-induced steatosis.
Pubmed identfication : 9653160 9714746
Qualifiers : classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics
RefSeq identity : NM_004893
Synonyms : macroH2A1.2
Synonyms gene name : H2A histone family, member Y
Tree numbers : E05.196.401.143 E05.301.300.096 E05.478.566.320.200 E05.601.262 E05.601.470.320.200
