Wnt3 alpha antibody

Product name : Wnt3 alpha antibody

Catalog number : MBS535903

Supplier : MBS Polyclonals

Price : 404 EUR

Size : 50ug

More about:

Concept : Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

Entrez Gene : wingless-type MMTV integration site family, member 3  (WNT3)

Gene :

Gene ontology - Biological process : animal organ morphogenesis cell-cell signaling limb bud formation stem cell proliferation anterior/posterior axis specification head morphogenesis negative regulation of axon extension involved in axon guidance canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation canonical Wnt signaling pathway involved in stem cell proliferation

Gene ontology - Cellular component : extracellular space cytoplasm extracellular region proteinaceous extracellular matrix

Gene ontology - Molecular function : protein binding receptor binding protein domain specific binding receptor agonist activity frizzled binding

InterPro : Wnt  (WIF1)  (WNT4) Wnt protein, conserved site Wnt-3 protein  (WNT3)

Kegg : Pathways in cancer - Mus musculus (mouse) Proteoglycans in cancer - Mus musculus (mouse) Wnt signaling pathway - Mus musculus (mouse) MicroRNAs in cancer - Mus musculus (mouse) HTLV-I infection - Mus musculus (mouse) Melanogenesis - Mus musculus (mouse) Hippo signaling pathway - Mus musculus (mouse) Hedgehog signaling pathway - Mus musculus (mouse) Basal cell carcinoma - Mus musculus (mouse)

Long gene name :

Name : Blotting, Western

PubMed : Secreted Wnt glycoproteins, expressed by thymic epithelial cells and thymocytes, regulate epithelial Foxn1 expression in both autocrine and paracrine fashions. Wnt molecules therefore provide regulatory signals critical for thymic function. Wnt-3a and Wnt-3 factors signal through the canonical Wnt/beta-catenin pathway to regulate different aspects of spinal cord neural progenitor development. We further delineate the role of Wnt signaling pathway as evidenced by induction of Wnt3 and Wnt8b, stimulation of FRP-1, inhibition of GSK-B, accumulation of cytosolic beta-catenin, and transcription of target genes, including c-myc and cyclin-D1. Data indicate that functional Wnt3/beta-Catenin signaling is localized to the dorsal subventricular zone (SVZ) microdomain. This study findings reveal the rich contributions of the Wnt3a lineage to a variety of brain structures and show that functionally integrated nuclei can share a molecular identity. Wnt3 expression in the epiblast is required for induction of the primitive streak and mesoderm whereas activity in the posterior visceral endoderm is dispensable. These results suggest that the regulation of paracrine factors plays a critical role in hippocampal aging and neurogenesis. Wnt3 function in the epiblast is required for the maintenance but not the initiation of gastrulation in mice timed secretion of wnt3 by ingrowing axons from the thalamus regulates the combinatorial composition of ribosomal proteins in developing neocortex. WNT3 further regulates the specificity of mRNA translation and development of neurons and oligodendrocytes. stem-cell membranes constitute a reservoir for Wnt proteins, while Frizzled receptor turnover and 'plasma membrane dilution' through cell division shape the epithelial Wnt3 gradient

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Tree numbers : E05.196.401.143 E05.301.300.096 E05.478.566.320.200 E05.601.262 E05.601.470.320.200

WikiPathWays : ESC Pluripotency Pathways Wnt Signaling Pathway NetPath Wnt Signaling Pathway Wnt Signaling Pathway and Pluripotency