anti-HMG-CoA Reductase Antibody

Product name : anti-HMG-CoA Reductase Antibody

Catalog number : 3952-100

Supplier : Biovision

Price : 338 EUR

Size : HMG-CoA Reductase Antibody

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Classification : Ring finger proteins

Concept : Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

Discovery year : 2004-07-28

Entrez Gene : 3-hydroxy-3-methylglutaryl-CoA reductase  (HMGCR)  (MIR509-3)

Entrez gene record : 84447

GenBank acession : AB085847

Gene : SYVN1

Gene ontology - Biological process : oxidation-reduction process visual learning positive regulation of smooth muscle cell proliferation aging protein tetramerization negative regulation of MAP kinase activity positive regulation of stress-activated MAPK cascade negative regulation of blood vessel diameter coenzyme A metabolic process myoblast differentiation

Gene ontology - Cellular component : endoplasmic reticulum membrane endoplasmic reticulum integral component of membrane peroxisomal membrane

Gene ontology - Molecular function : protein binding protein homodimerization activity protein phosphatase 2A binding NADPH binding coenzyme binding hydroxymethylglutaryl-CoA reductase (NADPH) activity hydroxymethylglutaryl-CoA reductase activity

Havana BLAST/BLAT : OTTHUMG00000165607

Identity : 20738

InterPro : Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain Hydroxymethylglutaryl-CoA reductase, class I/II Hydroxymethylglutaryl-CoA reductase, eukaryotic/archaeal type Sterol-sensing domain Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain Hydroxymethylglutaryl-CoA reductase, metazoan Hydroxymethylglutaryl-CoA reductase, N-terminal Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain

Kegg : AMPK signaling pathway - Homo sapiens (human) Terpenoid backbone biosynthesis - Homo sapiens (human) Bile secretion - Homo sapiens (human)

Locus : 11q13.1

Long gene name : synoviolin 1

Name : Blotting, Western

PubMed : Observational study of gene-disease association. (HuGE Navigator) Observational study of gene-disease association. (HuGE Navigator) Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) Observational study of gene-disease association. (HuGE Navigator) promoter DNA hypermethylation of the ABCG1 and GALNT2 genes, but not the HMGCR gene, is associated with an increased risk of CHD. Mevastatin inhibition of HMG-CoA reductase attenuates VCAM-1 expression in umbilical vein endothelial cells, but increases E-selectin expression, after TNF-alpha induction. Observational study of gene-disease association. (HuGE Navigator) The present study demonstrated that both SOD1 and the metal-free form of enzyme (Apo SOD1) inhibit HMG-CoA reductase gene expression in HepG2 cells, in normal human fibroblasts, and in fibroblasts of subjects affected by familiar hypercholesterolemia The HMGCR rs3846662 GG genotype was quantitatively documented to be a significant determinant for higher LDL-C level in basal state and possibly in response to atorvastatin. Increased cholesterol synthesis mediated by HMGCoA-R under inflammatory stress may be one of the mechanisms for intracellular lipid accumulation and statin resistance.

Pubmed identfication : 12975321

Qualifiers : classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics

RefSeq identity : NM_032431

Synonyms : HRD1 DER3

Synonyms gene name : synovial apoptosis inhibitor 1, synoviolin

Synonyms name : HMG-coA reductase degradation 1 homolog (S. cerevisiae)

Tree numbers : E05.196.401.143 E05.301.300.096 E05.478.566.320.200 E05.601.262 E05.601.470.320.200

WikiPathWays : AMP-activated Protein Kinase (AMPK) Signaling Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Visual Learning Sterol Regulatory Element-Binding Proteins (SREBP) signalling Statin Pathway Target Of Rapamycin (TOR) Signaling SREBF and miR33 in cholesterol and lipid homeostasis Activation of gene expression by SREBF (SREBP) Demo complete Demo