ARHGEF2 Over-expression Lysate reagent

Product name : ARHGEF2 Over-expression Lysate reagent

Catalog number : GWB-7E6D80

Supplier : genways

Price : 562 EUR

Size : 1 tube

More about:

Classification : Rho guanine nucleotide exchange factors Pleckstrin homology domain containing

Discovery year : 2000-06-09

Entrez Gene : rho/rac guanine nucleotide exchange factor (GEF) 2  (ARHGEF2)

Entrez gene record : 9181

GenBank acession : AB014551

Gene : ARHGEF2

Gene ontology - Biological process : positive regulation of transcription from RNA polymerase II promoter cell division positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production positive regulation of NF-kappaB transcription factor activity regulation of Rho protein signal transduction negative regulation of microtubule depolymerization cellular response to muramyl dipeptide establishment of mitotic spindle orientation negative regulation of podosome assembly

Gene ontology - Cellular component : cytoplasmic vesicle protein complex ruffle membrane cytoskeleton cell junction postsynaptic density of dendrite microtubule vesicle bicellular tight junction podosome

Gene ontology - Molecular function : protein binding metal ion binding Rac GTPase binding microtubule binding Rho GTPase binding guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity Rac guanyl-nucleotide exchange factor activity

Havana BLAST/BLAT : OTTHUMG00000017464

Identity : 682

InterPro : Pleckstrin homology domain  (PLEKHA7) PH domain-like  (AGAP4) Protein kinase C-like, phorbol ester/diacylglycerol-binding domain Dbl homology (DH) domain

Locus : 1q22

Long gene name : Rho/Rac guanine nucleotide exchange factor 2

PubMed : PAK4 mediates morphological changes through regulation of GEF-H1 p114-RhoGEF and Lfc are critically involved in Wnt-3a- and Dvl-induced RhoA activation and neurite retraction in N1E-115 cells. CAPN6 acts as a regulator of Rac1 and cell motility through interaction with GEF-H1. Microtubule-associated RhoGEF Lfc is required for the formation of the mitotic spindle during prophase/prometaphase. Thus, Lfc and Tctex-1 interact to regulate cortical neurogenesis, potentially by regulating mitotic spindle orientation. Depletion of GEF-H1 in the murine two-hit model of VILI attenuated vascular leak induced by lung ventilation at high tidal volume and thrombin-derived peptide TRAP6. LARG is activated by the Src family tyrosine kinase Fyn, whereas GEF-H1 catalytic activity is enhanced by ERK downstream of a signalling cascade that includes FAK and Ras Pak2, but not Pak1, negatively regulates RhoA via phosphorylation of the guanine nucleotide exchange factor GEF-H1 at an inhibitory site, leading to increased GEF-H1 microtubule binding and loss of RhoA stimulation Data show that the activation of the microtubule-associated guanine nucleotide exchange factor GEF-H1, encoded by Arhgef2, is essential for sensing of foreign RNA by RIG-I-like receptors. Study describes a new mode of GEF-H1 activation in response to G-protein-coupled receptor (GPCR) ligands that is independent of microtubule depolymerization.

Pubmed identfication : 9857026 9734811

RefSeq identity : NM_004723

Synonyms : LFP40 GEF-H1 KIAA0651 P40

Synonyms gene name : rho/rac guanine nucleotide exchange factor (GEF) 2 Rho/Rac guanine nucleotide exchange factor (GEF) 2

Tissue : lysate

Virus : lysate