ARHGEF25 Adenovirus (Human)

Product name : ARHGEF25 Adenovirus (Human)

Catalog number : 343157A

Supplier : abm Adinovirus

Price : Place ask EUR

Size : 250ul

More about:

Classification : Rho guanine nucleotide exchange factors

Discovery year : 2010-09-02

Entrez Gene : Rho guanine nucleotide exchange factor 25  (ARHGEF25)

Entrez gene record : 115557

Gene : ARHGEF25

Gene ontology - Biological process : positive regulation of GTPase activity regulation of Rho protein signal transduction

Gene ontology - Cellular component : cytosol plasma membrane myofibril sarcomere

Gene ontology - Molecular function : Rho guanyl-nucleotide exchange factor activity

Havana BLAST/BLAT : OTTHUMG00000152516

Identity : 30275

InterPro : Pleckstrin homology domain  (PLEKHA7) PH domain-like  (AGAP4) Dbl homology (DH) domain Rho guanine nucleotide exchange factor 25  (ARHGEF25)

Locus : 12q13.3

Long gene name : Rho guanine nucleotide exchange factor 25

PubMed : Results show that p63RhoGEF is a RhoA-specific GEF that may play a key role in actin cytoskeleton reorganization in different tissues, especially in heart cellular morphology. GEFT enhances dendritic spine formation and neurite outgrowth in primary neurons and neuroblastoma cells, respectively, through the activation of Rac/Cdc42-PAK signaling pathways. Together, our data provide new evidence suggesting that GEFT is an important regulator of multiple processes involved in axon and dendrite formation. MLK3 functions in a regulated way to limit levels of the activated GTPase Rho by binding to the Rho activator, p63RhoGEF/GEFT, which, in turn, prevents its activation by Galphaq. Specifically mediates angiotensin II- Gq/11-dependent RhoA activation and downstream signaling and processes in vascular smooth muscle cells p63RhoGEF is regulated chiefly through allosteric control by Galpha(q), as opposed to other known Galpha-regulated RhoGEFs, which are instead sequestered in the cytoplasm, perhaps because of their high basal activity. Signaling through p63RhoGEF provides a novel mechanism for selective regulation of blood pressure. Signaling efficiency of Galphaq through its effectors p63RhoGEF and GEFT depends on their subcellular location. assessed p63RhoGEF gene and protein expression and RhoA/Rho kinase activity in essential hypertensive and Bartter's and Gitelman's syndrome patients, a model opposite to hypertension p63RhoGEF can rapidly activate RhoA through endogenous G-protein coupled receptors.

Pubmed identfication : 12547822

RefSeq identity : NM_133483

Synonyms : GEFT p63RhoGEF

Synonyms gene name : Rho guanine nucleotide exchange factor (GEF) 25

Synonyms name : RAC/CDC42 exchange factor