ARHGEF4 Antibody

Product name : ARHGEF4 Antibody

Catalog number : E19-9864-2

Supplier : EnoGene

Price : 375 EUR

Size : 100ug/100ul

More about:

Classification : Rho guanine nucleotide exchange factors Pleckstrin homology domain containing

Concept : Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

Discovery year : 2000-04-11

Entrez Gene : Rho guanine nucleotide exchange factor 4  (ARHGEF4)

Entrez gene record : 50649

GenBank acession : AL137289

Gene : ARHGEF4

Gene ontology - Biological process : intracellular signal transduction positive regulation of GTPase activity regulation of small GTPase mediated signal transduction positive regulation of apoptotic process regulation of Rho protein signal transduction lamellipodium assembly filopodium assembly

Gene ontology - Cellular component : cytosol ruffle membrane

Gene ontology - Molecular function : protein binding protein domain specific binding guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity Rac guanyl-nucleotide exchange factor activity

Identity : 684

InterPro : Pleckstrin homology domain  (PLEKHA7) PH domain-like  (AGAP4) SH3 domain  (SBK1) Dbl homology (DH) domain Guanine-nucleotide dissociation stimulator, CDC24, conserved site

Kegg : Regulation of actin cytoskeleton - Homo sapiens (human)

Locus : 2q21.1

Long gene name : Rho guanine nucleotide exchange factor 4

Name : Blotting, Western

PubMed : Asef and APC function downstream of HGF and PI3-kinase, and play critical roles in growth factor-mediated regulation of cell morphology and migration These data demonstrate, that in addition to microtubule-independent Tiam1 activation, HGF engages additional microtubule- and APC-dependent pathway of Asef activation. these results demonstrate potent anti-inflammatory effects by HGF and delineate a key role of Asef in the mediation of the HGF barrier protective and anti-inflammatory effects. Positive role of Tyr94 phosphorylation in EGF-induced Asef activation following the activation of Rac1. Although inappropriate promoter methylation was not invariantly associated with reduced transcript expression, a significant association was apparent for the ARHGEF4, PON3, STAT5a, and VAX2 gene transcripts (P<0.05). Herein, we present the first genome-wide DNA methylation analysis in a unique HG-NMIBC cohort, showing extensive and discrete methylation changes relative to normal bladder and low-intermediate-grade tumor The crystal structure of the PreARM-ARM domain of human APC is complexed with the ABR-SH3 domains of human Asef. Small rare recurrent deletions and reciprocal duplications in 2q21.1, including brain-specific GPR148 Expression of Cdc42 (and Asef) together was associated with tubular injury with 100% specificity. Forced expression of Asef in vitro induced and maintained proliferation of haemaopoietic progenitor cells and co-operated with TEL-AML1 greatly to enhance proliferation and haemopoietic colony size

Pubmed identfication : 10873612

Qualifiers : classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics

Synonyms : STM6 KIAA1112 ASEF

Synonyms gene name : Rho guanine nucleotide exchange factor (GEF) 4

Synonyms name : APC-stimulated guanine nucleotide exchange factor

Tree numbers : E05.196.401.143 E05.301.300.096 E05.478.566.320.200 E05.601.262 E05.601.470.320.200

WikiPathWays : Regulation of Actin Cytoskeleton