ARHGEF5 Antibody

Product name : ARHGEF5 Antibody

Catalog number : E-AB-10830-200

Supplier : Elabscience

Price : 385.16 EUR

Size : 0,2 ml

More about:

Classification : Rho guanine nucleotide exchange factors

Concept : Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

Discovery year : 2001-02-15

Entrez Gene : Rho guanine nucleotide exchange factor 5  (ARHGEF35)

Entrez gene record : 7984

GenBank acession : U02082

Gene : ARHGEF5

Gene ontology - Biological process : positive regulation of sequence-specific DNA binding transcription factor activity regulation of small GTPase mediated signal transduction positive regulation of apoptotic process positive regulation of stress fiber assembly positive regulation of JUN kinase activity regulation of ERK1 and ERK2 cascade regulation of actin cytoskeleton organization regulation of GTPase activity actin cytoskeleton organization myeloid dendritic cell chemotaxis

Gene ontology - Cellular component : nucleus cytoplasm cytosol plasma membrane nucleoplasm cell junction cell projection cell periphery podosome

Gene ontology - Molecular function : protein binding GTP binding lipid binding guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity

Havana BLAST/BLAT : OTTHUMG00000158004

Identity : 13209

InterPro : Pleckstrin homology domain  (PLEKHA7) PH domain-like  (AGAP4) SH3 domain  (SBK1) Rho guanine nucleotide exchange factor 5/35, N-terminal Dbl homology (DH) domain Guanine-nucleotide dissociation stimulator, CDC24, conserved site

Locus : 7q35

Long gene name : Rho guanine nucleotide exchange factor 5

Name : Blotting, Western

PubMed : Observational study of gene-disease association. (HuGE Navigator) Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) The expression level of TIM was decreased in hepatocellular carcinoma. RhoA guanine nucleotide exchange factor Arhgef5 regulates immature dendritic cell migration Overexpression of Arhgef5 promoted actin stress fiber remodeling through activating RhoA, and the activation of RhoA or Cdc42 was required for Src-induced podosome formation. Tim-Tipin complex might play a role in coupling DNA unwinding and DNA synthesis by directly affecting the catalytic activities of replication fork proteins. In conclusion, ARHGEF5/Src can be considered as a prognostic biomarker and a therapeutic target for patients with resected NSCLC. A receiver operating characteristic curve constructed with HSP105 and TIM gave a sensitivity of 54.3% and 95% (38/40) specificity in discriminating esophageal squamous cell carcinoma from matched controls. Targeting rho guanine nucleotide exchange factor ARHGEF5/TIM with auto-inhibitory peptides in human breast cancer. Data indicate that Rho guanine nucleotide exchange factor 5 (ARHGEF5) is expressed in most human lung adenocarcinoma tissues and cell lines.

Pubmed identfication : 8134109 7656213

Qualifiers : classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics

RefSeq identity : NM_005435

Synonyms : TIM TIM1 GEF5 P60

Synonyms gene name : Rho guanine nucleotide exchange factor (GEF) 5

Synonyms name : transforming immortalized mammary oncogene guanine nucleotide regulatory protein TIM

Tree numbers : E05.196.401.143 E05.301.300.096 E05.478.566.320.200 E05.601.262 E05.601.470.320.200