ARHGEF5 Polyclonal Antibody

Product name : ARHGEF5 Polyclonal Antibody

Catalog number : CAA47880

Supplier : Biomatik

Price : Place ask EUR

Size : 100ug

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Classification : Rho guanine nucleotide exchange factors

Concept : Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

Discovery year : 2001-02-15

Entrez Gene : Rho guanine nucleotide exchange factor 5  (ARHGEF35)

Entrez gene record : 7984

GenBank acession : U02082

Gene : ARHGEF5

Gene ontology - Biological process : regulation of small GTPase mediated signal transduction positive regulation of apoptotic process positive regulation of stress fiber assembly positive regulation of JUN kinase activity regulation of Rho protein signal transduction regulation of actin cytoskeleton organization regulation of GTPase activity positive regulation of podosome assembly myeloid dendritic cell chemotaxis positive regulation of protein import

Gene ontology - Cellular component : nucleus cytoplasm cytosol plasma membrane nucleoplasm cell junction cell projection cell periphery podosome

Gene ontology - Molecular function : protein binding GTP binding lipid binding guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity

Havana BLAST/BLAT : OTTHUMG00000158004

Identity : 13209

InterPro : Pleckstrin homology domain  (PLEKHA7) PH domain-like  (AGAP4) SH3 domain  (SBK1) Rho guanine nucleotide exchange factor 5/35, N-terminal Dbl homology (DH) domain Guanine-nucleotide dissociation stimulator, CDC24, conserved site

Locus : 7q35

Long gene name : Rho guanine nucleotide exchange factor 5

Name : Blotting, Western

PubMed : Observational study of gene-disease association. (HuGE Navigator) Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) association in humans of TIM-1 and hypersensitivity and the relationship between TIM1, hygiene, and the environment. RhoA guanine nucleotide exchange factor Arhgef5 regulates immature dendritic cell migration Overexpression of Arhgef5 promoted actin stress fiber remodeling through activating RhoA, and the activation of RhoA or Cdc42 was required for Src-induced podosome formation. In conclusion, ARHGEF5/Src can be considered as a prognostic biomarker and a therapeutic target for patients with resected NSCLC. The auto-inhibitory state of Rho guanine nucleotide exchange factor ARHGEF5/TIM can be relieved by targeting its SH3 domain with rationally designed peptide aptamers. Targeting rho guanine nucleotide exchange factor ARHGEF5/TIM with auto-inhibitory peptides in human breast cancer. Data indicate that Rho guanine nucleotide exchange factor 5 (ARHGEF5) is expressed in most human lung adenocarcinoma tissues and cell lines. Tim protein and DDX11 physically and functionally interact and act in concert to preserve replication fork progression in perturbed conditions.

Pubmed identfication : 8134109 7656213

Qualifiers : classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics

RefSeq identity : NM_005435

Synonyms : TIM TIM1 GEF5 P60

Synonyms gene name : Rho guanine nucleotide exchange factor (GEF) 5

Synonyms name : transforming immortalized mammary oncogene guanine nucleotide regulatory protein TIM

Tree numbers : E05.196.401.143 E05.301.300.096 E05.478.566.320.200 E05.601.262 E05.601.470.320.200