ARHGEF6 Adenovirus (Human)

Product name : ARHGEF6 Adenovirus (Human)

Catalog number : 070341A

Supplier : abm Adinovirus

Price : 862 EUR

Size : 250ul

More about:

Classification : X-linked mental retardation Rho guanine nucleotide exchange factors Pleckstrin homology domain containing

Discovery year : 2000-07-27

Entrez Gene : Rac/Cdc42 guanine nucleotide exchange factor 6  (ARHGEF6)

Entrez gene record : 9459

GenBank acession : D13631

Gene : ARHGEF6

Gene ontology - Biological process : apoptotic process positive regulation of GTPase activity regulation of small GTPase mediated signal transduction positive regulation of apoptotic process JNK cascade regulation of Rho protein signal transduction lamellipodium assembly

Gene ontology - Cellular component : cytosol intracellular lamellipodium

Gene ontology - Molecular function : protein binding GTPase activator activity guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity

Havana BLAST/BLAT : OTTHUMG00000022518

Identity : 685

InterPro : Pleckstrin homology domain  (PLEKHA7) PH domain-like  (AGAP4) SH3 domain  (SBK1) Calponin homology domain  (LRCH1) Dbl homology (DH) domain Smooth muscle protein/calponin  (SMTNL1) Rho guanine nucleotide exchange factor, coiled-coil domain

Kegg : Regulation of actin cytoskeleton - Homo sapiens (human) Pancreatic cancer - Homo sapiens (human)

Locus : Xq26.3

Locus Specific Databases : Mental Retardation database

Long gene name : Rac/Cdc42 guanine nucleotide exchange factor 6

PubMed : The novel recycling regulator alpha-PIX and the degradation factor c-Cbl closely cooperate in the regulation of EGFR trafficking. Data suggest that Rac-dependent activation of the NFkappaB pathway may be a critical element promoting thrombin-induced tissue factor expression and activity, and thus a prothrombotic state in pulmonary hypertension. PAK4 and alphaPIX can induce highly localized changes in actin dynamics and thereby regulate size and number of podosomes in primary human macrophages. Observational study of gene-disease association. (HuGE Navigator) The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding Whereas alphaPIX guanine nucleotide exchange factor activity contributes to enhanced formation of cellular protrusions, the GEF-independent association with calpain 4 leads to induction of a yet unknown signaling cascade resulting in cell spreading. The interaction of alphaPix with CagA activates PAK1, ERK and NF-kappaB, which induces IL-8 expression in H. pylori-infected gastric epithelial cells. results suggest that low doses of chlorambucil and very low doses of chronic oxidative stress together kill Cbl-resistant ovarian carcinoma cells and ARHGEF6 signaling may have an instrumental role in induction of apoptosis in Cbl(cos) cells. These findings suggest that alpha Pix plays an important role in mutant huntingtin aggregation. c-Cbl negatively regulates alphaPix-mediated cell migration and invasion; the lack of c-Cbl in C6 and A172 glioma cells is responsible for their malignant behavior

Pubmed identfication : 7584048 9659915

RefSeq identity : NM_004840

Synonyms : alphaPIX Cool-2 KIAA0006 alpha-PIX Cool2

Synonyms gene : MRX46

Synonyms gene name : mental retardation, X-linked 46 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6

Synonyms name : Rac/Cdc42 guanine exchange factor (GEF) 6 PAK-interacting exchange factor, alpha rho guanine nucleotide exchange factor 6

WikiPathWays : Regulation of Actin Cytoskeleton