ARHGEF6 Antibody

Product name : ARHGEF6 Antibody

Catalog number : E-AB-16170-20

Supplier : Elabscience

Price : 107.96 EUR

Size : 0.02 ml

More about:

Classification : X-linked mental retardation Rho guanine nucleotide exchange factors Pleckstrin homology domain containing

Concept : Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

Discovery year : 2000-07-27

Entrez Gene : Rac/Cdc42 guanine nucleotide exchange factor 6  (ARHGEF6)

Entrez gene record : 9459

GenBank acession : D13631

Gene : MRX46

Gene ontology - Biological process : apoptotic process positive regulation of GTPase activity regulation of small GTPase mediated signal transduction positive regulation of apoptotic process JNK cascade regulation of Rho protein signal transduction lamellipodium assembly

Gene ontology - Cellular component : cytosol intracellular lamellipodium

Gene ontology - Molecular function : protein binding GTPase activator activity guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity

Havana BLAST/BLAT : OTTHUMG00000022518

Identity : 7278

InterPro : Pleckstrin homology domain  (PLEKHA7) PH domain-like  (AGAP4) SH3 domain  (SBK1) Calponin homology domain  (LRCH1) Dbl homology (DH) domain Smooth muscle protein/calponin  (SMTNL1) Rho guanine nucleotide exchange factor, coiled-coil domain

Kegg : Regulation of actin cytoskeleton - Homo sapiens (human) Pancreatic cancer - Homo sapiens (human)

Locus : Xq26.3

Locus Specific Databases : Mental Retardation database

Long gene name : symbol withdrawn, see ARHGEF6

Name : Blotting, Western

PubMed : PAK4 and alphaPIX can induce highly localized changes in actin dynamics and thereby regulate size and number of podosomes in primary human macrophages. Observational study of gene-disease association. (HuGE Navigator) Semi-quantitative RT-PCR experiments with 6 of those genes confirmed higher expression of DNCH2, ARHGEF6, NPM1 and SRI and lower expression of NRGN and TM4SF2 in GBM tumors. The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding Expression of Cbl-b effectively blocks the ability of Cool-2 to stimulate PAK, providing an additional mechanism, aside from catalyzing receptor ubiquitination, by which Cbl-b acts as a negative regulator for signaling activities requiring PAK activation. Whereas alphaPIX guanine nucleotide exchange factor activity contributes to enhanced formation of cellular protrusions, the GEF-independent association with calpain 4 leads to induction of a yet unknown signaling cascade resulting in cell spreading. phosphorylation of CagA induces the dephosphorylation of alpha-Pix, which may modulate cytoskeletal changes of gastric epithelial cells through PAK The interaction of alphaPix with CagA activates PAK1, ERK and NF-kappaB, which induces IL-8 expression in H. pylori-infected gastric epithelial cells. results suggest that low doses of chlorambucil and very low doses of chronic oxidative stress together kill Cbl-resistant ovarian carcinoma cells and ARHGEF6 signaling may have an instrumental role in induction of apoptosis in Cbl(cos) cells. These findings suggest that alpha Pix plays an important role in mutant huntingtin aggregation.

Pubmed identfication : 7584048 9659915

Qualifiers : classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics

RefSeq identity : NM_004840

Synonyms : alphaPIX Cool-2 KIAA0006 alpha-PIX Cool2

Synonyms gene : MRX46

Synonyms gene name : mental retardation, X-linked 46 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6

Synonyms name : Rac/Cdc42 guanine exchange factor (GEF) 6 PAK-interacting exchange factor, alpha rho guanine nucleotide exchange factor 6

Tree numbers : E05.196.401.143 E05.301.300.096 E05.478.566.320.200 E05.601.262 E05.601.470.320.200

WikiPathWays : Regulation of Actin Cytoskeleton