ARHGEF6 Antibody

Product name : ARHGEF6 Antibody

Catalog number : E-AB-16170-200

Supplier : Elabscience

Price : 385.16 EUR

Size : 0,2 ml

More about:

Classification : X-linked mental retardation Rho guanine nucleotide exchange factors Pleckstrin homology domain containing

Concept : Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

Discovery year : 2000-07-27

Entrez Gene : Rac/Cdc42 guanine nucleotide exchange factor 6  (ARHGEF6)

Entrez gene record : 9459

GenBank acession : D13631

Gene : MRX46

Gene ontology - Biological process : apoptotic process positive regulation of GTPase activity regulation of small GTPase mediated signal transduction positive regulation of apoptotic process JNK cascade regulation of Rho protein signal transduction lamellipodium assembly

Gene ontology - Cellular component : cytosol intracellular lamellipodium

Gene ontology - Molecular function : protein binding GTPase activator activity guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity

Havana BLAST/BLAT : OTTHUMG00000022518

Identity : 7278

InterPro : Pleckstrin homology domain  (PLEKHA7) PH domain-like  (AGAP4) SH3 domain  (SBK1) Calponin homology domain  (LRCH1) Dbl homology (DH) domain Smooth muscle protein/calponin  (SMTNL1) Rho guanine nucleotide exchange factor, coiled-coil domain

Kegg : Regulation of actin cytoskeleton - Homo sapiens (human) Pancreatic cancer - Homo sapiens (human)

Locus : Xq26.3

Locus Specific Databases : Mental Retardation database

Long gene name : symbol withdrawn, see ARHGEF6

Name : Blotting, Western

PubMed : The novel recycling regulator alpha-PIX and the degradation factor c-Cbl closely cooperate in the regulation of EGFR trafficking. Data suggest that Rac-dependent activation of the NFkappaB pathway may be a critical element promoting thrombin-induced tissue factor expression and activity, and thus a prothrombotic state in pulmonary hypertension. PAK4 and alphaPIX can induce highly localized changes in actin dynamics and thereby regulate size and number of podosomes in primary human macrophages. Semi-quantitative RT-PCR experiments with 6 of those genes confirmed higher expression of DNCH2, ARHGEF6, NPM1 and SRI and lower expression of NRGN and TM4SF2 in GBM tumors. The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding Expression of Cbl-b effectively blocks the ability of Cool-2 to stimulate PAK, providing an additional mechanism, aside from catalyzing receptor ubiquitination, by which Cbl-b acts as a negative regulator for signaling activities requiring PAK activation. phosphorylation of CagA induces the dephosphorylation of alpha-Pix, which may modulate cytoskeletal changes of gastric epithelial cells through PAK These findings suggest that alpha Pix plays an important role in mutant huntingtin aggregation. c-Cbl negatively regulates alphaPix-mediated cell migration and invasion; the lack of c-Cbl in C6 and A172 glioma cells is responsible for their malignant behavior show that ARHGEF6 is constitutively linked to GIT1, a GAP of Arf family small G proteins, and that ARHGEF6 phosphorylation enables binding of the 14-3-3 adaptor protein to the ARHGEF6/GIT1 complex

Pubmed identfication : 7584048 9659915

Qualifiers : classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics

RefSeq identity : NM_004840

Synonyms : alphaPIX Cool-2 KIAA0006 alpha-PIX Cool2

Synonyms gene : MRX46

Synonyms gene name : mental retardation, X-linked 46 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6

Synonyms name : Rac/Cdc42 guanine exchange factor (GEF) 6 PAK-interacting exchange factor, alpha rho guanine nucleotide exchange factor 6

Tree numbers : E05.196.401.143 E05.301.300.096 E05.478.566.320.200 E05.601.262 E05.601.470.320.200

WikiPathWays : Regulation of Actin Cytoskeleton