ARHGEF6 Lentiviral Vector (Human) (UbC) (pLenti-GIII-UbC)

Product name : ARHGEF6 Lentiviral Vector (Human) (UbC) (pLenti-GIII-UbC)

Catalog number : LV079628

Supplier : ABM lentivectors

Price : 1125 EUR

Size : 1.0 µg DNA

More about:

Classification : Phospholipases

Concept : Scope note: The transfer of bacterial DNA by phages from an infected bacterium to another bacterium. This also refers to the transfer of genes into eukaryotic cells by viruses. This naturally occurring process is routinely employed as a GENE TRANSFER TECHNIQUE.

Discovery year : 2002-04-29

Entrez Gene : ubiquitin C  (UBC)

Entrez gene record : 50487

GenBank acession : AF220490

Gene : PLA2G3

Gene ontology - Biological process : negative regulation of apoptotic process innate immune response MyD88-independent toll-like receptor signaling pathway I-kappaB kinase/NF-kappaB signaling Wnt signaling pathway, planar cell polarity pathway proteasome-mediated ubiquitin-dependent protein catabolic process JNK cascade ERBB2 signaling pathway error-prone translesion synthesis negative regulation of G2/M transition of mitotic cell cycle

Gene ontology - Cellular component : nucleus cytosol plasma membrane nucleoplasm extracellular exosome endoplasmic reticulum membrane endosome membrane myelin sheath endoplasmic reticulum quality control compartment endocytic vesicle membrane

Gene ontology - Molecular function : protein binding RNA binding protease binding

Havana BLAST/BLAT : OTTHUMG00000151255

Identity : 17934

InterPro : Ubiquitin-related domain Ubiquitin domain  (UBLCP1) Ubiquitin conserved site Ubiquitin  (USP51)

Kegg : PPAR signaling pathway - Homo sapiens (human)

Locus : 22q12.2

Locus Specific Databases : Mental Retardation database

Long gene name : phospholipase A2 group III

Name : Transduction, Genetic

PubMed : Data indicate that modification of NEMO with linear di-ubiquitin is sufficient for full NF-kappaB activation. Chicago Sky Blue 6B (CSB6B) binds directly to the beta-groove of ubiquitin and could inhibit the binding of ubiquitin to chemokine (C-X-C motif) receptor 4 (CXCR4), a cell surface ubiquitin receptor. Ubiquitin expression increased with increasing severity of coronary artery disease, suggesting that ubiquitin may play a critical role in the development and progression of this disease. Studies indicate that indicating that the inhibition of the ubiquitin-proteasome system could be used as a novel approach for cancer therapy. UbcH5c~Ubiqitin binding stabilizes an active conformation of the Shigella flexneri OspG kinase, greatly enhancing its activity. Data indicate that a single point deletion (DeltaE81) in RAP80 abrogates multivalent interactions with polyubiquitin. Studies indicate that ubiquitin proteasome system (UPS) controls all aspects of cholesterol metabolism including its synthesis, uptake, and efflux. Our study predicted that UBC and RPA had potential as target genes for the diagnosis and treatment of osteosarcoma Studies indicate a role for the ubiquitin-proteasome system (UPS) as a key regulator of ciliogenesis. Studies suggest that ubiquitin signals for the proteasome involved more that Lys48 (K48).

Pubmed identfication : 10713052

Qualifiers : classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics

RefSeq identity : NM_015715

Synonyms : GIII-SPLA2

Synonyms gene : MRX46

Synonyms gene name : phospholipase A2, group III

Synonyms name : Rac/Cdc42 guanine exchange factor (GEF) 6 PAK-interacting exchange factor, alpha rho guanine nucleotide exchange factor 6

Tree numbers : E05.393.350.800

WikiPathWays : Proteasome Degradation DNA Replication