Product name : ARHGEF6 siRNA

Catalog number : abx908069

Supplier : abbex

Price : 816 EUR

Size : 30 nmol

More about:

Classification : X-linked mental retardation Rho guanine nucleotide exchange factors Pleckstrin homology domain containing

Discovery year : 2000-07-27

Entrez Gene : Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6  (ARHGEF2)  (ARHGEF6)

Entrez gene record : 9459

GenBank acession : D13631

Gene : ARHGEF6

Gene ontology - Biological process : intracellular signal transduction regulation of Rho protein signal transduction lamellipodium assembly

Gene ontology - Cellular component : cell-cell junction lamellipodium cell projection

Gene ontology - Molecular function : protein binding guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity

Havana BLAST/BLAT : OTTHUMG00000022518

Identity : 685

InterPro : Pleckstrin homology domain  (PLEKHA7) PH domain-like  (AGAP4) SH3 domain  (SBK1) Calponin homology domain  (LRCH1) Dbl homology (DH) domain Guanine-nucleotide dissociation stimulator, CDC24, conserved site Smooth muscle protein/calponin  (SMTNL1) Rho guanine nucleotide exchange factor, coiled-coil domain

Kegg : Regulation of actin cytoskeleton - Mus musculus (mouse) Pancreatic cancer - Mus musculus (mouse)

Locus : Xq26.3

Locus Specific Databases : Mental Retardation database

Long gene name : Rac/Cdc42 guanine nucleotide exchange factor 6

PubMed : PAK3 regulates dendritic spines morphogenesis. The mouse Arhgef6 gene: cDNA sequence, expression analysis, and X chromosome assignment. These results reveal specific roles for alphaPIX in the immune system and suggest that redundancy with betaPIX precludes a more severe immune phenotype. suggest that imbalance in activity of different Rho GTPases may underlie altered neuronal connectivity and impaired synaptic function and cognition in alphaPix/Arhgef6 knockout mice alphaPIX and GIT2 are required for neuronal differentiation. Results indicate Arhgef6 (alphaPIX) as a regulator of thymocyte migration and subsequent arrest that is linked to positive selection. Enforced expression of miR-135a in highly tumorigenic cancer stem cells strongly inhibited tumorigenesis by repressing the miR-135a direct target gene Arhgef6. this study has identified a new role for Parvin and alphaPix downstream of the integrin-ILK signaling axis for mammary epithelial cell differentiation.

Pubmed identfication : 7584048 9659915

RefSeq identity : NM_004840

Synonyms : alphaPIX Cool-2 KIAA0006 alpha-PIX Cool2

Synonyms gene : MRX46

Synonyms gene name : mental retardation, X-linked 46 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6

Synonyms name : Rac/Cdc42 guanine exchange factor (GEF) 6 PAK-interacting exchange factor, alpha rho guanine nucleotide exchange factor 6

WikiPathWays : Regulation of Actin Cytoskeleton T Cell Receptor Signaling Pathway