ARHGEF7 Antibody

Product name : ARHGEF7 Antibody

Catalog number : A53117-050

Supplier : Epigen

Price : 302 EUR

Size : 0.05mg

More about:

Concept : Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

Discovery year : 2011-05-05

Entrez Gene : Rho guanine nucleotide exchange factor 7  (ARHGEF7)

Gene : ARHGEF7-AS2

Gene ontology - Biological process : signal transduction positive regulation of growth hormone secretion positive regulation of protein binding regulation of small GTPase mediated signal transduction positive regulation of apoptotic process positive regulation of fibroblast migration regulation of Rho protein signal transduction focal adhesion assembly Golgi organization regulation of GTP binding

Gene ontology - Cellular component : cytosol plasma membrane focal adhesion protein complex neuron projection neuronal cell body cell cortex lamellipodium ruffle storage vacuole

Gene ontology - Molecular function : protein binding protein kinase binding guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity

Havana BLAST/BLAT : OTTHUMG00000017353

Identity : 40717

InterPro : Pleckstrin homology domain  (PLEKHA7) PH domain-like  (AGAP4) SH3 domain  (SBK1) Calponin homology domain  (LRCH1) Variant SH3 domain  (ITSN1) Dbl homology (DH) domain Guanine-nucleotide dissociation stimulator, CDC24, conserved site Rho guanine nucleotide exchange factor, coiled-coil domain

Kegg : Regulation of actin cytoskeleton - Homo sapiens (human)

Locus : 13q34

Long gene name : ARHGEF7 antisense RNA 2

Name : Blotting, Western

PubMed : Conversely, increased expression of betaPIX in breast cancer cell lines re-couples the Hippo kinase cassette to Yap/Taz, promoting localization of Yap/Taz to the cytoplasm and inhibiting cell migration and proliferation. reorganization of subsarcolemmal cytoskeletal actin by activation of Rac1 through alpha and betaPIXs in skeletal muscle is mediatedby affixin Data show that Rac1 plays a significant role in the pathological adhesion of Schwannoma cells. Rac1 regulates nitric oxide synthase type 2 (NOD2) trafficking and NOD2-dependent signal transduction in primary human monocytes and cell line THP-1. GIT2 protein is tightly associated with PIX family Rac1/Cdc42 guanine nucleotide exchange factors as a multimeric nexus capable of linking together important signaling molecules. GIT1/betaPIX/Rac1/PAK pathway plays a crucial role in regulating GABA(A)R synaptic stability and hence inhibitory synaptic transmission with important implications for inhibitory plasticity and information processing in the brain. These data strongly suggest that, in addition to the known SAP-interacting kinase Fyn, PIX may be another key player in SAP-mediated T cell activation. PKA-dependent phosphorylation modulates PIXB activity through 14-3-3-beta binding. beta1Pix functions as a transcriptional regulator of beta-catenin signaling through direct interaction with beta-catenin, an action that may be functionally relevant to colon cancer biology. BetaPix phosphorylation at Ser-340 upregulates Nox1 through Rac activation.

Qualifiers : classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics

Synonyms gene name : ARHGEF7 antisense RNA 2 (non-protein coding)

Tree numbers : E05.196.401.143 E05.301.300.096 E05.478.566.320.200 E05.601.262 E05.601.470.320.200

WikiPathWays : Integrin-mediated Cell Adhesion Regulation of Actin Cytoskeleton