ARHGEF7 Antibody

Product name : ARHGEF7 Antibody

Catalog number : abx001025

Supplier : abbex

Price : 338 EUR

Size : 50 μl

More about:

Concept : Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

Discovery year : 2011-05-05

Entrez Gene : Rho guanine nucleotide exchange factor 7  (ARHGEF7)

Gene : ARHGEF7-AS2

Gene ontology - Biological process : signal transduction positive regulation of GTPase activity regulation of small GTPase mediated signal transduction positive regulation of apoptotic process positive regulation of fibroblast migration positive regulation of substrate adhesion-dependent cell spreading ephrin receptor signaling pathway negative regulation of epidermal growth factor receptor signaling pathway lamellipodium assembly regulation of GTP binding

Gene ontology - Cellular component : cytosol plasma membrane focal adhesion protein complex neuron projection neuronal cell body cell cortex lamellipodium ruffle storage vacuole

Gene ontology - Molecular function : protein binding protein kinase binding guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity

Havana BLAST/BLAT : OTTHUMG00000017353

Identity : 40717

InterPro : Pleckstrin homology domain  (PLEKHA7) PH domain-like  (AGAP4) SH3 domain  (SBK1) Calponin homology domain  (LRCH1) Variant SH3 domain  (ITSN1) Dbl homology (DH) domain Guanine-nucleotide dissociation stimulator, CDC24, conserved site Rho guanine nucleotide exchange factor, coiled-coil domain

Kegg : Regulation of actin cytoskeleton - Homo sapiens (human)

Locus : 13q34

Long gene name : ARHGEF7 antisense RNA 2

Name : Blotting, Western

PubMed : PAK1 recruitment to the T cell-antigen-presenting cell interface required interaction with PIX. the SH3 domain of betaPix specifically interacts with a proline-arginine motif (PxxxPR) present within the ubiquitin ligase Cbl and Pak1 kinase. Cbl and Pak1 compete for binding to betaPix. MYO18A is a novel binding partner of the PAK2/betaPIX/GIT1 complex and suggest that MYO18A may play an important role in regulating epithelial cell migration via affecting multiple cell machineries. Data show that podocalyxin overexpression in human embryonic kidney cells up-regulates Rac1 activity, which depends on a complex formed by podocalyxin, ERM-binding phosphoprotein 50, ezrin, and ARHGEF7, a Rac1 activator. Phosphorylation of LRRK2 by casein kinase 1alpha regulates trans-Golgi clustering via differential interaction with ARHGEF7. reorganization of subsarcolemmal cytoskeletal actin by activation of Rac1 through alpha and betaPIXs in skeletal muscle is mediatedby affixin GIT1/betaPIX/Rac1/PAK pathway plays a crucial role in regulating GABA(A)R synaptic stability and hence inhibitory synaptic transmission with important implications for inhibitory plasticity and information processing in the brain. PKA-dependent phosphorylation modulates PIXB activity through 14-3-3-beta binding. Results describe the role of beta-Pix in the negative regulation of focal adhesion maturation and the promotion of lamellipodial protrusion and focal adhesion turnover to drive cell migration. It has identified and characterized a novel interaction between CaM and beta-p21-activated kinase interacting exchange factor (beta-PIX), a putative guanine exchange factor implicated in cell signaling.

Qualifiers : classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics

Synonyms gene name : ARHGEF7 antisense RNA 2 (non-protein coding)

Tree numbers : E05.196.401.143 E05.301.300.096 E05.478.566.320.200 E05.601.262 E05.601.470.320.200

WikiPathWays : Integrin-mediated Cell Adhesion Regulation of Actin Cytoskeleton