ARHGEF7 Antibody

Product name : ARHGEF7 Antibody

Catalog number : E-AB-14609-20

Supplier : Elabscience

Price : 107.96 EUR

Size : 0.02 ml

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Concept : Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

Discovery year : 2011-05-05

Entrez Gene : Rho guanine nucleotide exchange factor 7  (ARHGEF7)

Gene : ARHGEF7-AS2

Gene ontology - Biological process : signal transduction positive regulation of growth hormone secretion positive regulation of protein binding positive regulation of GTPase activity nervous system development regulation of small GTPase mediated signal transduction positive regulation of substrate adhesion-dependent cell spreading regulation of Rho protein signal transduction focal adhesion assembly lamellipodium assembly

Gene ontology - Cellular component : cytosol plasma membrane focal adhesion protein complex neuron projection neuronal cell body cell cortex lamellipodium ruffle storage vacuole

Gene ontology - Molecular function : protein binding protein kinase binding guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity

Havana BLAST/BLAT : OTTHUMG00000017353

Identity : 40717

InterPro : Pleckstrin homology domain  (PLEKHA7) PH domain-like  (AGAP4) SH3 domain  (SBK1) Calponin homology domain  (LRCH1) Variant SH3 domain  (ITSN1) Dbl homology (DH) domain Guanine-nucleotide dissociation stimulator, CDC24, conserved site Rho guanine nucleotide exchange factor, coiled-coil domain

Kegg : Regulation of actin cytoskeleton - Homo sapiens (human)

Locus : 13q34

Long gene name : ARHGEF7 antisense RNA 2

Name : Blotting, Western

PubMed : Conversely, increased expression of betaPIX in breast cancer cell lines re-couples the Hippo kinase cassette to Yap/Taz, promoting localization of Yap/Taz to the cytoplasm and inhibiting cell migration and proliferation. Up-regulation of CXCR4 by inhibiting glycogen synthase kinase (GSK)-3beta enhances mesenchymal stromal cell migration. Rac1 interaction with beta-Pix (p21-activated kinase [Pak]-interacting exchange factor) is required for Rac1 activation by beta-Pix as well as for Rac1-mediated spreading reorganization of subsarcolemmal cytoskeletal actin by activation of Rac1 through alpha and betaPIXs in skeletal muscle is mediatedby affixin Rac1 regulates nitric oxide synthase type 2 (NOD2) trafficking and NOD2-dependent signal transduction in primary human monocytes and cell line THP-1. betaPIX and GIT1 regulate the hepatocyte growth factor-induced and Rac1-dependent membrane transport of WAVE2 and consequently, lamellipodia formation. GIT2 protein is tightly associated with PIX family Rac1/Cdc42 guanine nucleotide exchange factors as a multimeric nexus capable of linking together important signaling molecules. PKA-dependent phosphorylation modulates PIXB activity through 14-3-3-beta binding. These results identify p66Shc and FOXO3a as novel partners of beta(1)Pix and represent the first direct evidence of beta(1)Pix in cell proliferation via Erk/p66Shc-dependent and Akt-independent mechanisms. BETA-PIX is a novel downstream signalling mediator during invadopodia formation.

Qualifiers : classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics

Synonyms gene name : ARHGEF7 antisense RNA 2 (non-protein coding)

Tree numbers : E05.196.401.143 E05.301.300.096 E05.478.566.320.200 E05.601.262 E05.601.470.320.200

WikiPathWays : Integrin-mediated Cell Adhesion Regulation of Actin Cytoskeleton