ARID1A Antibody - C-terminal region

Product name : ARID1A Antibody - C-terminal region

Catalog number : OAAB20886

Supplier : aviva

Price : 424 EUR

Size : one vial

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Classification : AT-rich interaction domain containing

Concept : Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

Discovery year : 2000-06-26

Entrez Gene : AT rich interactive domain 1A (SWI-like)  (ARID1A)  (SMARCA1)

Entrez gene record : 8289

GenBank acession : AB001895

Gene : ARID1A

Gene ontology - Biological process : negative regulation of transcription from RNA polymerase II promoter regulation of transcription, DNA-templated covalent chromatin modification chromatin remodeling stem cell population maintenance cardiac muscle cell differentiation toxin transport glucocorticoid receptor signaling pathway formation of primary germ layer cardiac chamber development

Gene ontology - Cellular component : nucleus nucleoplasm nuclear chromatin SWI/SNF complex npBAF complex nBAF complex BAF-type complex

Gene ontology - Molecular function : protein binding DNA binding ligand-dependent nuclear receptor binding nucleosome binding

Havana BLAST/BLAT : OTTHUMG00000004004

Identity : 11110

InterPro : ARID DNA-binding domain  (HLA-DOA) Armadillo-type fold Armadillo-like helical SWI/SNF-like complex subunit BAF250/Osa  (ARID1A)  (SMARCA1) SWI/SNF-like complex subunit BAF250, C-terminal  (ARID1A)  (SMARCA1) SWI/SNF-like complex subunit BAF250a  (SMARCA1)

Locus : 1p36.11

Locus Specific Databases : LRG_875

Long gene name : AT-rich interaction domain 1A

Name : Blotting, Western

PubMed : Our results indicate that the Arid1a tumour suppressor gene has a key role in regulating ovarian endometrioid carcinoma differentiation The patterns of expression of ARID1A and ARID1B genes through various mouse embryonic stages, was examined. ARID1A and PIK3CA mutations cooperate to promote tumour growth through sustained IL-6 overproduction. Data show that the Baf250a(E2E3/E2E3) FL-derived stroma, in contrast, exhibits a hemopoiesis-supporting potential superior to the developmentally matched controls. Results demonstrate that inactivation of Arid1a alone is insufficient for tumor initiation but it requires additional genetic alteration(s) such as Pten deletion to drive tumorigenesis. The Baf250a orchestrated a genetic program that repressed the expression of Nkx2.5 in the SAN through Tbx3 and HDAC3 BAF250a mediates esBAF and polycomb recessive complex functions to establish the poised chromatin configuration in embryonic stem (ES) cells, which is essential for ES cell differentiation. This study provides an alternative mechanism by which Arid1a deficiency contributes to hepatocellular carcinoma tumorigenesis. regulates embryo implantation and development of a functional placenta The Arid1a loss reprograms chromatin to restrict promoter access by transcription factors such as C/ebpalpha, which enforces differentiation, and E2F4, which suppresses cell-cycle re-entry.

Pubmed identfication : 9630625 9434167

Qualifiers : classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics

RefSeq identity : NM_139135

Synonyms : B120 P270 C10rf4 BAF250 BAF250a

Synonyms gene : C1orf4 SMARCF1

Synonyms gene name : SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily f, member 1 AT rich interactive domain 1A (SWI- like) AT rich interactive domain 1A (SWI-like)

Tree numbers : E05.196.401.143 E05.301.300.096 E05.478.566.320.200 E05.601.262 E05.601.470.320.200