ARID1A Antibody

Product name : ARID1A Antibody

Catalog number : E-AB-12984-60

Supplier : Elabscience

Price : 158.36 EUR

Size : 0.06 ml

More about:

Classification : AT-rich interaction domain containing

Concept : Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

Discovery year : 2000-06-26

Entrez Gene : AT-rich interaction domain 1A  (ARID1A)  (NBN)

Entrez gene record : 8289

GenBank acession : AB001895

Gene : C1orf4

Gene ontology - Biological process : negative regulation of transcription from RNA polymerase II promoter chromatin remodeling forebrain development stem cell population maintenance cardiac muscle cell differentiation neural tube closure embryo implantation chromatin-mediated maintenance of transcription optic cup formation involved in camera-type eye development nucleosome mobilization

Gene ontology - Cellular component : nucleus nucleoplasm nuclear chromatin SWI/SNF complex npBAF complex nBAF complex

Gene ontology - Molecular function : protein binding DNA binding transcription coactivator activity ligand-dependent nuclear receptor binding nucleosome binding

Havana BLAST/BLAT : OTTHUMG00000004004

Identity : 1235

InterPro : ARID DNA-binding domain  (HLA-DOA) Armadillo-type fold Armadillo-like helical SWI/SNF-like complex subunit BAF250/Osa  (ARID1A)  (SMARCA1) SWI/SNF-like complex subunit BAF250, C-terminal  (ARID1A)  (SMARCA1) SWI/SNF-like complex subunit BAF250a  (SMARCA1)

Locus : 1p36.11

Locus Specific Databases : LRG_875

Long gene name : AT-rich interaction domain 1A

Name : Blotting, Western

PubMed : loss of ARID1A protein expression caused by inactivating mutations reactivates TERT transcriptional activity and confers a survival advantage of tumor cells by maintaining their telomeres. P53 expression may be a negative prognostic factor in endometrial clear cell carcinomas in the primary breast carcinoma, transforming ARID1A sequence was an antisense cDNA, and was the product of a genomic rearrangement; identified a lung adenocarcinoma cell line with a highly localized homozygous genomic deletion in the 5' end of ARID1A Data confirm that loss of the ARID1A-encoded protein BAF250a is a frequent event in the genesis of clear cell and endometrioid ovarian cancers. Loss of BAF250a was not associated with clinical or epidemiologic characteristics. study demonstrates that in-frame indel mutations of ARID1A, are associated with the loss of ability to suppress cellular proliferation and activate CDKN1A (p21) transcription Data indicate enhanced cell growth, proliferation and invasion were observed on ARID1A knockdown in esophageal adenocarcinoma (EAC) cells. Suggest that loss of ARID1A expression, presumably due to mutation, plays an important role in tumor progression of uterine endometrioid carcinoma. Loss of AT-rich interactive domain 1A expression is associated with gastrointestinal malignancies. A significant trend of association was found between histologic grade and ARID1A expression ARID1A positively regulates Klf15 expression with PGR to inhibit epithelial proliferation at peri-implantation. Our results suggest that Arid1a has a critical role in modulating epithelial proliferation which is a critical requisite for fertility

Pubmed identfication : 9630625 9434167

Qualifiers : classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics

RefSeq identity : NM_139135

Synonyms : B120 P270 C10rf4 BAF250 BAF250a ARID1A

Synonyms gene : SMARCF1

Synonyms gene name : SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily f, member 1 AT rich interactive domain 1A (SWI- like) AT rich interactive domain 1A (SWI-like)

Tree numbers : E05.196.401.143 E05.301.300.096 E05.478.566.320.200 E05.601.262 E05.601.470.320.200

WikiPathWays : Pathways Affected in Adenoid Cystic Carcinoma miR-targeted genes in lymphocytes - TarBase miR-targeted genes in muscle cell - TarBase miR-targeted genes in epithelium - TarBase Prostate Cancer