ARID1A Antibody

Product name : ARID1A Antibody

Catalog number : PB9685

Supplier : boster

Price : 374 EUR

Size : 0,1 mg

More about:

Classification : AT-rich interaction domain containing

Concept : Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

Discovery year : 2000-06-26

Entrez Gene : AT-rich interaction domain 1A  (ARID1A)  (NBN)

Entrez gene record : 8289

GenBank acession : AB001895

Gene : C1orf4

Gene ontology - Biological process : negative regulation of transcription from RNA polymerase II promoter transcription, DNA-templated covalent chromatin modification ATP-dependent chromatin remodeling maintenance of chromatin silencing forebrain development cardiac muscle cell differentiation toxin transport nucleosome disassembly placenta blood vessel development

Gene ontology - Cellular component : nucleus nucleoplasm nuclear chromatin SWI/SNF complex npBAF complex nBAF complex

Gene ontology - Molecular function : protein binding DNA binding transcription coactivator activity ligand-dependent nuclear receptor binding nucleosome binding

Havana BLAST/BLAT : OTTHUMG00000004004

Identity : 1235

InterPro : ARID DNA-binding domain  (HLA-DOA) Armadillo-type fold Armadillo-like helical SWI/SNF-like complex subunit BAF250/Osa  (ARID1A)  (SMARCA1) SWI/SNF-like complex subunit BAF250, C-terminal  (ARID1A)  (SMARCA1) SWI/SNF-like complex subunit BAF250a  (SMARCA1)

Locus : 1p36.11

Locus Specific Databases : LRG_875

Long gene name : AT-rich interaction domain 1A

Name : Blotting, Western

PubMed : largest subunits of SWI/SNF participate in promoting transcriptional activation by the steroid hormone receptors The mutation spectrum for ARID1A differs between molecular subtypes of gastric cancer, and mutation prevalence is negatively associated with mutations in TP53 Loss of ARID1A has different and pathway-dependent roles in gastric carcinoma. Loss of ARID1A appears to be an early event in the carcinogenesis of endometrioid uterine carcinomas and the association with deep myometrial infiltration may suggest an importance for invasiveness. BAF250a-encoding ARID1A has the capacity to play a tumor-suppressive role in breast cancer. loss of ARID1A expression occurs in a small but significant proportion of colorectal carcinomas where it is strongly correlated with mismatch repair deficiency in invasive urothelial carcinoma of urinary bladder, low ARID1A expression showed a tendency for lower risk of tumor progression and cancer mortality. we focus on the relationships of ARID1A mutations with ovarian and endometrial cancers[review] Identification of this undescribed functional NLS within ARID1A contributes vital insights to rationalize the impact of ARID1A missense mutations observed in patient tumors. Complete or partial loss of ARID1A expression is considered an independent poor prognostic factor in patients with gastric cancer.

Pubmed identfication : 9630625 9434167

Qualifiers : classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics

RefSeq identity : NM_139135

Synonyms : B120 P270 C10rf4 BAF250 BAF250a ARID1A

Synonyms gene : SMARCF1

Synonyms gene name : SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily f, member 1 AT rich interactive domain 1A (SWI- like) AT rich interactive domain 1A (SWI-like)

Tree numbers : E05.196.401.143 E05.301.300.096 E05.478.566.320.200 E05.601.262 E05.601.470.320.200

WikiPathWays : Pathways Affected in Adenoid Cystic Carcinoma miR-targeted genes in lymphocytes - TarBase miR-targeted genes in muscle cell - TarBase miR-targeted genes in epithelium - TarBase Prostate Cancer