ARID1B Antibody, ALEXA FLUOR 594

Product name : ARID1B Antibody, ALEXA FLUOR 594

Catalog number : bs-12520R-A594

Supplier : Bioss Primary Conjugated Antibodies. ALEXA FLUOR

Price : 332.75 EUR

Size : 100ul

More about:

Classification : AT-rich interaction domain containing

Concept : Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

Discovery year : 2004-01-28

Entrez Gene : AT-rich interaction domain 1B  (ARID1B)  (NBN)

Entrez gene record : 57492

GenBank acession : AF521671

Gene : ARID1B

Gene ontology - Biological process : transcription, DNA-templated covalent chromatin modification neuron-neuron synaptic transmission dendritic spine development chromatin-mediated maintenance of transcription dendritic cell dendrite assembly

Gene ontology - Cellular component : cytosol plasma membrane nucleoplasm SWI/SNF complex nBAF complex

Gene ontology - Molecular function : protein binding DNA binding transcription coactivator activity

Havana BLAST/BLAT : OTTHUMG00000015890

Identity : 18040

InterPro : ARID DNA-binding domain  (HLA-DOA) Armadillo-type fold Armadillo-like helical SWI/SNF-like complex subunit BAF250/Osa  (ARID1A)  (SMARCA1) SWI/SNF-like complex subunit BAF250, C-terminal  (ARID1A)  (SMARCA1)

Locus : 6q25.3

Locus Specific Databases : LRG_861

Long gene name : AT-rich interaction domain 1B

Name : Blotting, Western

PubMed : BAF complex gene SMARCA4 is mutated in Coffin-Siris syndrome patients. 6A3-5 expression is associated with alpha-smooth muscle cell actin in mesangial cells, arteriolar smooth muscle cells, and interstitial myofibroblasts.could potentially be a novel early vascular marker of acute and chronic renal ischemic stress Analysis of DNA-binding behaviour indicates that ARID1B binds DNA in a non-sequence-specific manner similar to ARID1A Haploinsufficiency of ARID1B, a member of the SWI/SNF-A chromatin-remodeling complex, is a common cause of ID. associations revealed between genetic polymorphisms located in the flanking region of the ARID1B genes and hypoesthesia Phenotype of Coffin-Siris syndrome patients with ARID1B mutations ARID1B potentially serves as a valuable prognostic and predictive biomarker as well as a therapeutic target in breast cancer. Results show the crystal structure and binding site of SWI1 protein and identify loop L1 and L2 regions of SWI1 ARID likely play key roles in ARID-DNA interactions. Gonadal mosaicism in ARID1B gene causes intellectual disability and dysmorphic features in three siblings. Chromosome analysis by array-CGH revealed a small interstitial 6q deletion spanning approximately 1.1 Mb of DNA and containing only one coding gene, ARID1B. We suggest that ARID1B is the key gene behind 6q microdeletion syndrome, and we discuss its possible role in the phenotypic manifestations

Qualifiers : classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics

RefSeq identity : NM_020732

Synonyms : KIAA1235 ELD/OSA1 p250R BAF250b DAN15 6A3-5

Synonyms gene name : AT rich interactive domain 1B (SWI1-like)

Tree numbers : E05.196.401.143 E05.301.300.096 E05.478.566.320.200 E05.601.262 E05.601.470.320.200

WikiPathWays : Prostate Cancer