ARID3A antibody

Product name : ARID3A antibody

Catalog number : 10R-1240

Supplier : fitzgerald

Price : 284 EUR

Size : 50 µg

More about:

Classification : AT-rich interaction domain containing

Concept : Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

Discovery year : 1997-08-22

Entrez Gene : AT-rich interaction domain 3A  (ARID3A)  (NBN)

Entrez gene record : 1820

GenBank acession : U88047

Gene : ARID3A

Gene ontology - Biological process : positive regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

Gene ontology - Cellular component : nucleus cytosol nucleoplasm intracellular membrane-bounded organelle membrane raft

Gene ontology - Molecular function : protein binding RNA polymerase II regulatory region sequence-specific DNA binding protein homodimerization activity chromatin binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding

Havana BLAST/BLAT : OTTHUMG00000182018

Identity : 3031

InterPro : ARID DNA-binding domain  (HLA-DOA) REKLES domain

Locus : 19p13.3

Long gene name : AT-rich interaction domain 3A

Name : Blotting, Western

PubMed : These results indicate both cooperative and interdependent roles for ARID3A and p53 in the transcriptional activation of p21(WAF1) in response to DNA damage. Analysis of flanking sequences of IgH and Ig kappa V region genes show extensive heterogeneity in frequency and location of CDP binding sites and capability of CDP to bind to the nuclear matrix. role in p53 regulatory pathway.(E2FBP1) Bright is not expressed in all human B lymphocyte subpopulations. report that E2FBP1 inhibits accumulation of ICP0 RNA and, at the same time, is degraded via ICP0's herpes ubiquitin ligase 2 (HUL-2) activity upon HSV-1 infection. functions as a critical antagonist to the p16(INK4A)-Rb tumor suppressor machinery by regulating promyelocytic leukemia protein stability These findings support the hypothesis that Epstein-Barr virus EBNA1 initiates transcription at the C promoter via interactions between multiple EBNA1 homodimers and cellular transcription such as E2F1, ARID3A and Oct-2. miR-125b can act as an oncogene in B-cell acute lymphoblastic leukemia by targeting ARID3a and mediating its repression. Systemic lupus erythematosus (SLE) patients had increased ARID3a B cells compared to healthy controls. ARID3a was not expressed in naive B cells of controls, but was abundant in SLE patients. Number of ARID3a B cells correlated with disease activity. results suggest that appropriate regulation of ARID3a is critical for normal development of both myeloid and B lineage pathways.

Pubmed identfication : 9722953

Qualifiers : classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics

RefSeq identity : NM_005224

Synonyms : BRIGHT

Synonyms gene : DRIL1

Synonyms gene name : dead ringer-like 1 (Drosophila) AT rich interactive domain 3A (BRIGHT- like) AT rich interactive domain 3A (BRIGHT-like)

Tree numbers : E05.196.401.143 E05.301.300.096 E05.478.566.320.200 E05.601.262 E05.601.470.320.200

WikiPathWays : TP53 Regulates Transcription of Cell Cycle Genes