ARID3A (AT-rich Interactive Domain-containing Protein 3A, ARID Domain-containing Protein 3A, B-cell Regulator of IgH Transcription, Bright, Dead Ringer-like Protein 1, E2F-binding Protein 1, DRIL1, DRIL3, DRX, E2FBP1) Antibody

Product name : ARID3A (AT-rich Interactive Domain-containing Protein 3A, ARID Domain-containing Protein 3A, B-cell Regulator of IgH Transcription, Bright, Dead Ringer-like Protein 1, E2F-binding Protein 1, DRIL1, DRIL3, DRX, E2FBP1) Antibody

Catalog number : GEN648036

Supplier : MBS Monoclonals

Price : 779 EUR

Size : 50ug

More about:

Classification : BRCA1 C complex MRN complex

Concept : Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

Discovery year : 1997-11-28

Entrez Gene : AT-rich interaction domain 3A  (ARID3A)  (NBN)

Entrez gene record : 4683

GenBank acession : AF058696

Gene : NBN

Gene ontology - Biological process : positive regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

Gene ontology - Cellular component : nucleus cytosol nucleoplasm intracellular membrane-bounded organelle membrane raft

Gene ontology - Molecular function : protein binding RNA polymerase II regulatory region sequence-specific DNA binding protein homodimerization activity chromatin binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding

Havana BLAST/BLAT : OTTHUMG00000153546

Identity : 7652

InterPro : ARID DNA-binding domain  (HLA-DOA) REKLES domain

Locus : 8q21.3

Locus Specific Databases : LOVD - Leiden Open Variation Database LRG_158

Long gene name : nibrin

Name : Blotting, Western

PubMed : These results indicate both cooperative and interdependent roles for ARID3A and p53 in the transcriptional activation of p21(WAF1) in response to DNA damage. Analysis of flanking sequences of IgH and Ig kappa V region genes show extensive heterogeneity in frequency and location of CDP binding sites and capability of CDP to bind to the nuclear matrix. Results show that DRIL1 disrupts cellular protection against RAS(V12)-induced proliferation downstream of the p19(ARF)/p53 pathway. a putative p53-binding site was found, which specifically responded to p53, in the second intron of the E2FBP1/DRIL1 gene Bright is not expressed in all human B lymphocyte subpopulations. TFII-I directly interacts with Bright through amino acids in Bright's protein interaction domain Bright/ARID3a inhibition causes increased developmental plasticity in mouse and human cells. These findings support the hypothesis that Epstein-Barr virus EBNA1 initiates transcription at the C promoter via interactions between multiple EBNA1 homodimers and cellular transcription such as E2F1, ARID3A and Oct-2. These data reveal new functions for ARID3a in early hematopoiesis and suggest that knowledge regarding ARID3a levels in HSPCs could be informative for applications requiring transplantation of those cells. Data indicate ARID3a( ) B cells as a type of effector B cell, and link ARID3a expression in B lymphocytes to interferon alpha (IFNa)-associated inflammatory responses in systemic lupus erythematosus (SLE).

Pubmed identfication : 9590181 9590180

Qualifiers : classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics

RefSeq identity : NM_001024688

Synonyms : ATV AT-V2 AT-V1

Synonyms gene : NBS NBS1

Synonyms gene name : Nijmegen breakage syndrome 1 (nibrin)

Tree numbers : E05.196.401.143 E05.301.300.096 E05.478.566.320.200 E05.601.262 E05.601.470.320.200

WikiPathWays : TP53 Regulates Transcription of Cell Cycle Genes