ARID3A (AT-rich Interactive Domain-containing Protein 3A, ARID Domain-containing Protein 3A, B-cell Regulator of IgH Transcription, Bright, Dead Ringer-like Protein 1, E2F-binding Protein 1, DRIL1, DRIL3, DRX, E2FBP1)

Product name : ARID3A (AT-rich Interactive Domain-containing Protein 3A, ARID Domain-containing Protein 3A, B-cell Regulator of IgH Transcription, Bright, Dead Ringer-like Protein 1, E2F-binding Protein 1, DRIL1, DRIL3, DRX, E2FBP1)

Catalog number : GEN646424

Supplier : MBS Monoclonals

Price : 619 EUR

Size : 100ug

More about:

Classification : BRCA1 C complex MRN complex

Discovery year : 1997-11-28

Entrez Gene : AT-rich interaction domain 3A  (ARID3A)  (NBN)

Entrez gene record : 4683

GenBank acession : AF058696

Gene : NBN

Gene ontology - Biological process : positive regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

Gene ontology - Cellular component : nucleus cytosol nucleoplasm intracellular membrane-bounded organelle membrane raft

Gene ontology - Molecular function : protein binding RNA polymerase II regulatory region sequence-specific DNA binding protein homodimerization activity chromatin binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding

Havana BLAST/BLAT : OTTHUMG00000153546

Identity : 7652

InterPro : ARID DNA-binding domain  (HLA-DOA) REKLES domain

Locus : 8q21.3

Locus Specific Databases : LOVD - Leiden Open Variation Database LRG_158

Long gene name : nibrin

PubMed : Id1 inhibited DNA binding by Dril1, and the two proteins co-localized in vitro and in vivo, providing a potential mechanism for suppression of fibrosis by Id1 through inhibition of the profibrotic function of Dril1. role in p53 regulatory pathway.(E2FBP1) a putative p53-binding site was found, which specifically responded to p53, in the second intron of the E2FBP1/DRIL1 gene TFII-I directly interacts with Bright through amino acids in Bright's protein interaction domain identify Bright as a contributor to accessibility of the IgH enhancer A palmitoylated pool of Bright is diverted to lipid rafts of resting B cells where it associates with signalosome components. Solution NMR structure of the ARID domain of human ARID3A. functions as a critical antagonist to the p16(INK4A)-Rb tumor suppressor machinery by regulating promyelocytic leukemia protein stability These findings support the hypothesis that Epstein-Barr virus EBNA1 initiates transcription at the C promoter via interactions between multiple EBNA1 homodimers and cellular transcription such as E2F1, ARID3A and Oct-2. These data reveal new functions for ARID3a in early hematopoiesis and suggest that knowledge regarding ARID3a levels in HSPCs could be informative for applications requiring transplantation of those cells.

Pubmed identfication : 9590181 9590180

RefSeq identity : NM_001024688

Synonyms : ATV AT-V2 AT-V1

Synonyms gene : NBS NBS1

Synonyms gene name : Nijmegen breakage syndrome 1 (nibrin)

WikiPathWays : TP53 Regulates Transcription of Cell Cycle Genes