Assay kit for Ataxin-8(ATXN8) (ELISA)

Product name : Assay kit for Ataxin-8(ATXN8) (ELISA)

Catalog number : E02A1774 -96T

Supplier : BlueGen ELISAs

Price : 780 EUR

Size : 1x96-wells test plate

More about:

Classification : Ataxins

Concept : Scope note: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.

Discovery year : 2006-07-18

Entrez Gene : ataxin 8  (ATXN8)

Entrez gene record : 724066

GenBank acession : DQ641254

Gene : ATXN8

Gene ontology - Cellular component : nucleus

Identity : 32925

Locus : 13q21.33

Long gene name : ataxin 8

Name : Enzyme-Linked Immunosorbent Assay

PubMed : expression of noncoding (CUG)n expansion transcripts (ataxin 8 opposite strand, ATXN8OS) and the discovery of intranuclear polyglutamine inclusions suggests SCA8 pathogenesis involves toxic gain-of-function mechanisms at both the protein and RNA levels CUG-repeat expansion is toxic and affects ATXN8 RNA expression and stability through epigenetic and post-transcriptional. mechanisms. Observational study of gene-disease association. (HuGE Navigator) Observational study of gene-disease association. (HuGE Navigator) The spinocerebellar ataxia type 8 is caused by Trinucleotide Repeat Expansion in ataxin 8 protein. Report a fluorescent PCR method for detection of expanded repeats in the ATXN8OS/ATXN8 gene in spinocerebellar ataxia type 8. This study identified only one patient with an SCA8 expansion in Greek patients with Huntington's disease. suggest that ATXN8 -62 G/A polymorphism plays a role in Taiwanese Parkinson's disease susceptibility

Pubmed identfication : 16804541

Qualifiers : adverse effects, classification, economics, history, instrumentation, methods, mortality, nursing, psychology, standards, trends, utilization, veterinary, statistics & numerical data, contraindications, ethics

Tree numbers : E05.478.566.350.170 E05.478.566.380.360 E05.478.583.400.170 E05.601.470.350.170 E05.601.470.380.360