Assay kit for autoantibodies against the C-terminal domain Ⅳ,ACAST-DⅣ (ELISA)

Product name : Assay kit for autoantibodies against the C-terminal domain Ⅳ,ACAST-DⅣ (ELISA)

Catalog number : E02A2138 -48T

Supplier : BlueGen ELISAs

Price : 605 EUR

Size : 1x48-wells test plate

More about:

Concept : Scope note: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.

Discovery year : 2001-06-29

Entrez Gene : KIT proto-oncogene receptor tyrosine kinase  (KIT)

Entrez gene record : 89837

GenBank acession : BC023564

Gene : ULK4P3

Gene ontology - Biological process : hemopoiesis positive regulation of MAPK cascade activation of MAPK activity positive regulation of JAK-STAT cascade response to cadmium ion epithelial cell proliferation dendritic cell cytokine production lamellipodium assembly regulation of developmental pigmentation melanocyte migration

Gene ontology - Cellular component : extracellular space plasma membrane integral component of membrane external side of plasma membrane cell-cell junction mast cell granule cytoplasmic side of plasma membrane acrosomal vesicle

Gene ontology - Molecular function : protein binding ATP binding transmembrane receptor protein tyrosine kinase activity protein homodimerization activity protein tyrosine kinase activity Ras guanyl-nucleotide exchange factor activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity signal transducer, downstream of receptor, with protein tyrosine kinase activity cytokine binding stem cell factor receptor activity

Havana BLAST/BLAT : OTTHUMG00000175637

Identity : 15777

InterPro : Protein kinase domain  (PKDCC) Protein kinase-like domain Immunoglobulin-like fold Tyrosine-protein kinase, active site Tyrosine-protein kinase, receptor class III, conserved site  (CPLX3) Tyrosine-protein kinase, catalytic domain Immunoglobulin-like domain  (ILDR1) Immunoglobulin subtype 2 Mast/stem cell growth factor receptor Tyrosine-protein kinase, CSF-1/PDGF receptor family  (CSF1)  (CSF2)  (PDGFA)

Kegg : PI3K-Akt signaling pathway - Homo sapiens (human) Acute myeloid leukemia - Homo sapiens (human) Breast cancer - Homo sapiens (human) Hematopoietic cell lineage - Homo sapiens (human) Pathways in cancer - Homo sapiens (human) Melanogenesis - Homo sapiens (human) Ras signaling pathway - Homo sapiens (human) Rap1 signaling pathway - Homo sapiens (human) Endocytosis - Homo sapiens (human) Phospholipase D signaling pathway - Homo sapiens (human)

Locus : 15q13.2

Long gene name : ULK4 pseudogene 3

Name : Enzyme-Linked Immunosorbent Assay

PubMed : Frequently mutated in seminoma germ cell tumors, but not associated with bilateral disease as opposed to unilateral. cardiac atrium contains a small C-kit CD45- population expressing markers commonly found on endothelial progenitor cells High CD117 antigen is associated with chromophobe renal cell carcinoma. The proximity of undifferentiated gonadal tissue with the tumors as well as the immunostaining patterns (PLAP , OCT3/4 , and CD117/KIT ) suggests that germ cells found in them are a risk factor for gonadal tumors. There was statistically significant difference in KIT expression between clinically non-functioning, growth hormone- and adrenocorticotroph hormone-producing adenomas report of a female patient with clear cell sarcoma exhibiting both EWSR1-ATF1 fusion transcripts and hereditary homozygous point mutations in introns 11 and 16 of the KIT gene; parents and two brothers each had heterozygous point mutations in intron 11 or intron 16 of the KIT gene MAPK functions as a redundant survival signal that reinforces the PI3K cascade in c-Kit mutant melanoma. Data indicate differential patterns of gene amplification and expression of receptor tyrosine kinases PDGFRA, KIT, and VEGFR2 at the 4q12 locus to be associated with specific phenotypes. KIT mutations in primary mediastinal B-cell lymphoma. Residual ovarian carcinoma tumors were more frequently present in the patients with positive CD117 expression.

Pubmed identfication : 11829490

Qualifiers : adverse effects, classification, economics, history, instrumentation, methods, mortality, nursing, psychology, standards, trends, utilization, veterinary, statistics & numerical data, contraindications, ethics

Synonyms : D-X

Synonyms gene : FAM7A3

Synonyms gene name : family with sequence similarity 7, member A3 unc-51-like kinase 4 (C. elegans) pseudogene 3

Tree numbers : E05.478.566.350.170 E05.478.566.380.360 E05.478.583.400.170 E05.601.470.350.170 E05.601.470.380.360

WikiPathWays : Focal Adhesion-PI3K-Akt-mTOR-signaling pathway Differentiation Pathway miR-targeted genes in lymphocytes - TarBase miR-targeted genes in muscle cell - TarBase miR-targeted genes in epithelium - TarBase Cardiac Progenitor Differentiation Kit receptor signaling pathway