Assay kit for B7.H3 gene (ELISA)

Product name : Assay kit for B7.H3 gene (ELISA)

Catalog number : E02B0004 -48T

Supplier : BlueGen ELISAs

Price : 605 EUR

Size : 1x48-wells test plate

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Classification : C2-set domain containing CD molecules V-set domain containing

Concept : Scope note: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.

Discovery year : 2005-03-04

Entrez Gene : KIT proto-oncogene receptor tyrosine kinase  (KIT)

Entrez gene record : 80381

GenBank acession : AF302102

Gene : CD276

Gene ontology - Biological process : positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of cell proliferation activation of MAPK activity actin cytoskeleton reorganization somatic stem cell population maintenance spermatid development melanocyte differentiation positive regulation of pseudopodium assembly somatic stem cell division melanocyte migration

Gene ontology - Cellular component : extracellular space plasma membrane integral component of membrane external side of plasma membrane cell-cell junction mast cell granule cytoplasmic side of plasma membrane acrosomal vesicle

Gene ontology - Molecular function : protein binding ATP binding protein homodimerization activity protein tyrosine kinase activity metal ion binding protease binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity signal transducer, downstream of receptor, with protein tyrosine kinase activity cytokine binding stem cell factor receptor activity

Havana BLAST/BLAT : OTTHUMG00000137585

Identity : 19137

InterPro : Protein kinase, ATP binding site  (VPS9D1) Protein kinase domain  (PKDCC) Protein kinase-like domain Immunoglobulin-like fold Tyrosine-protein kinase, active site Tyrosine-protein kinase, catalytic domain Serine-threonine/tyrosine-protein kinase catalytic domain Immunoglobulin  (IGHV3-29) Mast/stem cell growth factor receptor Tyrosine-protein kinase, CSF-1/PDGF receptor family  (CSF1)  (CSF2)  (PDGFA)

Kegg : PI3K-Akt signaling pathway - Homo sapiens (human) Acute myeloid leukemia - Homo sapiens (human) Breast cancer - Homo sapiens (human) Cytokine-cytokine receptor interaction - Homo sapiens (human) Hematopoietic cell lineage - Homo sapiens (human) Pathways in cancer - Homo sapiens (human) Melanogenesis - Homo sapiens (human) Ras signaling pathway - Homo sapiens (human) Rap1 signaling pathway - Homo sapiens (human) Phospholipase D signaling pathway - Homo sapiens (human)

Locus : 15q24.1

Long gene name : CD276 molecule

Name : Enzyme-Linked Immunosorbent Assay

PubMed : gain-of-function mutation in exon 11 of the c-kit gene is an important prognostic factor for gastrointestinal mesenchymal tumors, including myogenic and neurogenic tumors as well as GISTs The activated KIT in turn induces phosphorylation and activation of Cbl proteins The mutation of V604I of KIT gene is the cause of clinical phenotype of the family with piebaldism. Early myeloid cells expressing GNNK or GNNK-c-KIT show different responses to stem cell factor. c-kit and PDGFR-alpha mutation in EGISTs was essentially similar to that in GISTs KIT gene mutation is very rare in adenoid cystic carcinoma, and gene mutation is not the cause of protein overexpression. The biology of KIT mutations in both conditions, as well as the value of KIT mutation testing in predicting disease and treatment outcomes are discussed. CDC37 is a crucial HSP90-cofactor for KIT oncogenic expression in gastrointestinal stromal tumors KIT mutation is associated with mast cell neoplasms. Our data support those recently published in a meta-analysis on 1487 patients proving that GISTs bearing KIT mutations have a significantly poorer prognosis than either PDGFRA mutated or WT GISTs

Pubmed identfication : 11224528 12055244

Qualifiers : adverse effects, classification, economics, history, instrumentation, methods, mortality, nursing, psychology, standards, trends, utilization, veterinary, statistics & numerical data, contraindications, ethics

RefSeq identity : NM_025240

Synonyms : B7-H3 B7H3 B7RP-2

Synonyms gene name : CD276 antigen

Tree numbers : E05.478.566.350.170 E05.478.566.380.360 E05.478.583.400.170 E05.601.470.350.170 E05.601.470.380.360

WikiPathWays : Focal Adhesion-PI3K-Akt-mTOR-signaling pathway Differentiation Pathway miR-targeted genes in lymphocytes - TarBase miR-targeted genes in muscle cell - TarBase miR-targeted genes in epithelium - TarBase Cardiac Progenitor Differentiation Kit receptor signaling pathway