Austrelaps superbus Long neurotoxin 2

Product name : Austrelaps superbus Long neurotoxin 2

Catalog number : GEN1145090.E.coli

Supplier : MBS Recombinant

Price : 1293 EUR

Size : 1000ug

More about:

Alternative name : Austrelaps superbus large neurotoxin 2

Alternative names : Alpha-elapitoxin-As2a; Alpha-elapitoxin-As2a; Long neurotoxin 2; LNTX-2

Entrez Gene : ribonuclease A family member 2

Expression system : E. coli

Gene :

Gene ontology - Biological process : neutrophil degranulation positive regulation of protein targeting to mitochondrion chemotaxis defense response to Gram-positive bacterium defense response to Gram-negative bacterium defense response to virus induction of bacterial agglutination RNA phosphodiester bond hydrolysis, endonucleolytic RNA phosphodiester bond hydrolysis RNA catabolic process

Gene ontology - Cellular component : extracellular region extracellular exosome azurophil granule lumen

Gene ontology - Molecular function : nucleic acid binding lipopolysaccharide binding endonuclease activity ribonuclease activity ribonuclease A activity

Gene target : Austrelaps   superbus   Long   neurotoxin   2  

General description : Long neurotoxin 2 is a recombinant protein expressed in E. coli. The protein can be with or without a His-Tag or other tag in accordance to customer's request. All of our recombinant proteins are manufactured in strictly controlled facilities and by using a well established technology which guarantees full batch-to-bact consistency and experiment reproducibility.

InterPro : Ribonuclease A, active site Pancreatic ribonuclease  (RNASE1) Ribonuclease A-domain  (PNLDC1)

Long gene name :

Long name : Recombinant Austrelaps superbus Long neurotoxin 2

Other gene names : Alpha-EPTX-As2a; LNTX-2

PubMed : Observational study of gene-disease association. (HuGE Navigator) MAZ and Sp1 play important roles on the transcriptional activation of the human edn promoter through specific binding to a 34-nt segment present in representative primate eosinophil rnase promoters. Results reveal the dendritic cell-activating activity of pancreatic ribonuclease and suggest that it is a likely participant of inflammatory and immune responses--an endogenous multifunctional immune alarmin. Results describe the crystal structure of placental ribonuclease inhibitor in complex with eosinophil-derived neurotoxin, and a mutational analysis based on this structure. ECP and EDN disrupt skin integrity and cause inflammation atomic resolution structure crystal structure of a post-translationally modified form of eosinophil-derived neurotoxin (EDN) with four extra residues on its N terminus ((-4)EDN) has been solved and refined at atomic resolution (1 A) evidence for glycosylphosphatidylinositol (GPI)-anchored neurotoxin on granulocytes Data show that uEPX/c levels did not correlate with established markers of asthma severity and eosinophilic airway inflammation in atopic asthmatic children. the roles of the six discrete segments in transcription regulation were investigated and the -350/-329 region (ednR2) was shown to be involved in the regulation of edn expression

Short name : Austrelaps superbus Long neurotoxin 2