Austrelaps superbus Long neurotoxin 2

Product name : Austrelaps superbus Long neurotoxin 2

Catalog number : GEN1145090.Yeast

Supplier : MBS Recombinant

Price : 1796 EUR

Size : 1000ug

More about:

Alternative name : Austrelaps superbus large neurotoxin 2

Alternative names : Alpha-elapitoxin-As2a; Alpha-elapitoxin-As2a; Long neurotoxin 2; LNTX-2

Entrez Gene : ribonuclease A family member 2

Expression system : Yeast

Gene :

Gene ontology - Biological process : neutrophil degranulation positive regulation of protein targeting to mitochondrion chemotaxis defense response to Gram-positive bacterium defense response to Gram-negative bacterium defense response to virus induction of bacterial agglutination RNA phosphodiester bond hydrolysis, endonucleolytic RNA phosphodiester bond hydrolysis RNA catabolic process

Gene ontology - Cellular component : extracellular region extracellular exosome azurophil granule lumen

Gene ontology - Molecular function : nucleic acid binding lipopolysaccharide binding endonuclease activity ribonuclease activity ribonuclease A activity

Gene target : Austrelaps   superbus   Long   neurotoxin   2  

General description : Long neurotoxin 2 is a recombinant protein expressed in Yeast . The protein can be with or without a His-Tag or other tag in accordance to customer's request. All of our recombinant proteins are manufactured in strictly controlled facilities and by using a well established technology which guarantees full batch-to-bact consistency and experiment reproducibility.

InterPro : Ribonuclease A, active site Pancreatic ribonuclease  (RNASE1) Ribonuclease A-domain  (PNLDC1)

Long gene name :

Long name : Recombinant Austrelaps superbus Long neurotoxin 2

Other gene names : Alpha-EPTX-As2a; LNTX-2

PubMed : Observational study of gene-disease association. (HuGE Navigator) MAZ and Sp1 play important roles on the transcriptional activation of the human edn promoter through specific binding to a 34-nt segment present in representative primate eosinophil rnase promoters. Results reveal the dendritic cell-activating activity of pancreatic ribonuclease and suggest that it is a likely participant of inflammatory and immune responses--an endogenous multifunctional immune alarmin. Results describe the crystal structure of placental ribonuclease inhibitor in complex with eosinophil-derived neurotoxin, and a mutational analysis based on this structure. Elevated osteopontin in urine is associated with ovarian cancer crystal structure of a post-translationally modified form of eosinophil-derived neurotoxin (EDN) with four extra residues on its N terminus ((-4)EDN) has been solved and refined at atomic resolution (1 A) evidence for glycosylphosphatidylinositol (GPI)-anchored neurotoxin on granulocytes Urinary concentrations of eosinophil-derived neurotoxin in patients with atopic dermatitis show a significant positive correlation with disease severity. A higher level of serum EDN was found specifically in patients with ALS, indicating that EDN may participate in the pathophysiology of Amyotrophic lateral sclerosis. Serum EDN level may be a useful marker for monitoring persistent airflow limitation in adult patients with asthma who had positive results for house-dust-specific IgE antibodies.

Short name : Austrelaps superbus Long neurotoxin 2