BMI1 Polyclonal Antibody

Product name : BMI1 Polyclonal Antibody

Catalog number : A53945-100

Supplier : EpiGentek

Price : Place ask EUR

Size : 100 µg

More about:

Alternative name : BMI1 polyclonal (Antibody to)

Concept : Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

Discovery year : 2013-05-08

Entrez Gene : Bmi1 polycomb ring finger oncogene  (BMI1P1)

Entrez gene record : 100532731

Gene : COMMD3-BMI1

Gene ontology - Biological process : negative regulation of transcription from RNA polymerase II promoter transcription, DNA-templated histone acetylation positive regulation of immature T cell proliferation in thymus in utero embryonic development brain development DNA methylation cellular process rostrocaudal neural tube patterning embryonic skeletal system morphogenesis

Gene ontology - Cellular component : nucleus cytoplasm heterochromatin PcG protein complex ubiquitin ligase complex nuclear body

Gene ontology - Molecular function : protein binding chromatin binding sequence-specific DNA binding metal ion binding RNA polymerase II core promoter proximal region sequence-specific DNA binding promoter-specific chromatin binding ubiquitin-protein transferase activator activity

Gene target : BMI1  

Havana BLAST/BLAT : OTTHUMG00000184031

Identity : 48326

InterPro : Zinc finger, RING/FYVE/PHD-type  (MTMR3) Zinc finger, RING-type  (RNF113A) Zinc finger, RING-type, conserved site RAWUL domain

Kegg : Transcriptional misregulation in cancer - Mus musculus (mouse) MicroRNAs in cancer - Mus musculus (mouse)

Locus : 10p12.2

Long gene name : COMMD3-BMI1 readthrough

Name : Blotting, Western

PubMed : Bmi-1 is essential for the generation of self-renewing adult haematopoietic stem cells Bmi-1 is required for the self-renewal of stem cells in the peripheral and central nervous systems but not for their survival or differentiation Juxtaposed polycomb complex between EED and BMI1 in upstream regulatory regions of Hox genes regulate vertebral identity. show that Bmi1 is critical for multipotency of hematopoietic stem cells (HSCs) and multipotent progenitors (MPPs). A crucial role for BMI-1 in osteosarcoma pathogenesis. Bmi1-expressing stem cells may represent both a reserve stem cell pool in case of injury to the small intestine epithelium and a source for replenishment of the Lgr5-expressing cells under non-pathological conditions Bmi-1 plays an important role in the progression of pancreatic cancer and represents a novel target for antitumor therapy of pancreatic cancer. Bmi1 overlaps with the nascent Gata6 and Nanog protein from the eight-cell stage onward before it preferentially cosegregates with Gata6 in primitive endoderm progenitors Because miR-200 represses Bmi1, induction of ZEB1 leads to induction of Bmi1. Rb1 pathway status then dictates the opposing effects of mutant Ras on the ZEB1-miR-200 loop in primary versus cancer cells. Bmi1 deletion could substitute for Gata4 during iCM reprogramming. Thus, Bmi1 acts as a critical epigenetic barrier to iCM production. Bypassing this barrier simplifies iCM generation and increases yield, potentially streamlining iCM production for therapeutic purposes.

Qualifiers : classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics

Short name : BMI1 Polyclonal Antibody

Technique : Polyclonal, Antibody

Tree numbers : E05.196.401.143 E05.301.300.096 E05.478.566.320.200 E05.601.262 E05.601.470.320.200

WikiPathWays : Senescence and Autophagy