BMI1 (Polycomb Complex Protein BMI-1, Polycomb Group RING Finger Protein 4, RING Finger Protein 51, BMI1, PCGF4, RNF51) Antibody

Product name : BMI1 (Polycomb Complex Protein BMI-1, Polycomb Group RING Finger Protein 4, RING Finger Protein 51, BMI1, PCGF4, RNF51) Antibody

Catalog number : MBS625868

Supplier : MBS Polyclonals

Price : 597 EUR

Size : 200ul

More about:

Classification : Polycomb group ring fingers Ring finger proteins

Concept : Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

Discovery year : 2013-05-08

Entrez Gene : BMI1 proto-oncogene, polycomb ring finger  (BMI1P1)  (COMMD3-BMI1)

Entrez gene record : 100532731

GenBank acession : BC011652

Gene : COMMD3-BMI1

Gene ontology - Biological process : negative regulation of transcription from RNA polymerase II promoter transcription, DNA-templated hemopoiesis covalent chromatin modification regulation of gene expression positive regulation of fibroblast proliferation segment specification negative regulation of gene expression, epigenetic positive regulation of ubiquitin-protein transferase activity

Gene ontology - Cellular component : nucleus cytosol nucleoplasm PcG protein complex PRC1 complex ubiquitin ligase complex nuclear body

Gene ontology - Molecular function : protein binding zinc ion binding promoter-specific chromatin binding RING-like zinc finger domain binding

Havana BLAST/BLAT : OTTHUMG00000184031

Identity : 48326

InterPro : Zinc finger, RING/FYVE/PHD-type  (MTMR3) Zinc finger, RING-type  (RNF113A) Zinc finger, RING-type, conserved site RAWUL domain

Kegg : Transcriptional misregulation in cancer - Homo sapiens (human) Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) MicroRNAs in cancer - Homo sapiens (human)

Locus : 10p12.2

Long gene name : COMMD3-BMI1 readthrough

Name : Blotting, Western

PubMed : transcripotional control of Th2 memory cell generation EZH2 and BMI-1 are upregulated in osteosarcoma. EZH2 and BMI-1 may be useful targets for cancer immunotherapy of osteosarcoma, although knock-down of EZH2 and BMI-1 could not prevent osteosarcoma growth. Expression of Bmi-1 might be important in the acquisition of an invasive and/or aggressive phenotype of ovarian carcinoma, and serve as a independent biomarker for shortened survival time of patients. data suggest that the PS domain of BMI1 is involved in its stability and that it negatively regulates function of BMI1 oncoprotein Bmi-1/Mel-18 ratio can be potentially used as a tool for stratifying women at risk of developing breast malignancy. Bmi-1 siliencing combined treatment of doxorubicin might be a new strategy for biological treatment on breast cancer. Epithelial-mesenchymal transition and cancer stemness: the Twist1-Bmi1 connection expression patterns of ALDH1 and Bmi1 in OE were associated with malignant transformation, suggesting they may be valuable predictors for evaluating risk of oral cancer. We found that overexpression of c-Myc was significantly associated with that of BMI1, and that patients who harbored glioblastomas overexpressing c-Myc and BMI1 showed significantly longer overall survival. The Bmi-1 pathway was downregulated in GBM cells.

Pubmed identfication : 8268912

Qualifiers : classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics

RefSeq identity : NM_005180

Synonyms : RNF51

Synonyms gene : PCGF4

Synonyms gene name : polycomb group ring finger 4 B lymphoma Mo-MLV insertion region 1 homolog (mouse)

Tree numbers : E05.196.401.143 E05.301.300.096 E05.478.566.320.200 E05.601.262 E05.601.470.320.200

WikiPathWays : Senescence and Autophagy in Cancer