Bml-210, HDAC inhibitor

Product name : Bml-210, HDAC inhibitor

Catalog number : SIH-348-5MG

Supplier : stressma

Price : 259 EUR

Size : 5 mg

More about:

Classification : Histone deacetylases, class IIA

Discovery year : 2000-11-28

Entrez Gene : phosphatidylethanolamine binding protein 1  (PEBP1P2)

Entrez gene record : 9759

GenBank acession : AB006626

Gene : HDAC4

Gene ontology - Biological process : MAPK cascade negative regulation of endopeptidase activity

Gene ontology - Cellular component : nucleus cytosol extracellular exosome

Gene ontology - Molecular function : protein binding ATP binding RNA binding serine-type endopeptidase inhibitor activity protein kinase binding enzyme binding phosphatidylethanolamine binding

Havana BLAST/BLAT : OTTHUMG00000133344

Identity : 14063

InterPro : Phosphatidylethanolamine-binding, conserved site Phosphatidylethanolamine-binding protein  (PEBP1P2)

Locus : 2q37.3

Long gene name : histone deacetylase 4

PubMed : investigated the direct role of YY1 in the regulation of EMT. This review discusses the molecular regulation of EMT in cancer cells through the activity of the dysregulated NF-kappaB/Snail/ YY1/PTEN/RKIP circuitry BACH1 acts in a double-negative (overall positive) feedback loop to inhibit RKIP transcription in breast cancer cells down-regulation of RKIP expression is a major factor in activation of the IGF-I/ERK/MAPK pathway during human hepatocarcinogenesis These results demonstrating the absence of a disease-specific SNP in the HCNPpp promoter region suggest that the decrease in expression of this gene in late-onset AD patients can manifest from transcriptional or posttranscriptional changes in activity. ligand binding of PEBP1 RKIP inhibited the migration and invasion of SGC7901 cells. Furthermore, we observed that RKIP inhibited the growth of SMGC7901 cells in xenografts in nude mice Here, we review RKIP's role as a metastasis suppressor and the signaling networks and genes regulated by RKIP in metastatic, triple-negative breast cancer. [review] RKIP is upregulated in heart failure. report of the expression profile of RKIP in a heterogeneous group of soft tissue sarcomas; findings showed that only a small subset of cases exhibited RKIP loss, yet its loss is an independent biomarker of prognosis RKIP inhibitors locostatin reduces extracellular matrix production as well as the migration and proliferation of myometrial and leiomyoma cells.

Pubmed identfication : 10206986 10220385 20691407

RefSeq identity : NM_006037

Synonyms : KIAA0288 HDAC-A HDACA HD4 HA6116 HDAC-4

Synonyms gene : BDMR

Synonyms gene name : brachydactyly-mental retardation syndrome

WikiPathWays : EGF-EGFR Signaling Pathway