Bml 259, CDK5, p25 kinase inhibitor

Product name : Bml 259, CDK5, p25 kinase inhibitor

Catalog number : SIH-435-5MG

Supplier : StressMarq

Price : 5 EUR

Size : 131

More about:

Classification : Cyclin dependent kinases

Discovery year : 1993-07-28

Entrez Gene : tubulin polymerization promoting protein  (TPPP)

Entrez gene record : 1020

GenBank acession : X66364

Gene : CDK5

Gene ontology - Biological process : positive regulation of protein complex assembly microtubule bundle formation microtubule polymerization positive regulation of protein polymerization

Gene ontology - Cellular component : nucleus cytoplasm cytosol mitochondrion perinuclear region of cytoplasm microtubule myelin sheath microtubule bundle

Gene ontology - Molecular function : protein binding tubulin binding microtubule binding

Havana BLAST/BLAT : OTTHUMG00000158414

Identity : 1774

InterPro : EF-hand domain pair  (TSFM) P25-alpha  (TPPP) Tubulin polymerisation-promoting protein family member 1

Locus : 7q36.1

Long gene name : cyclin dependent kinase 5

PubMed : SIRT2 inhibition rescues alpha-synuclein (SYN)-mediated oligodendroglial apoptotic cell death accompanied by increased number of intracellular inclusions in a model of multiple system atrophy Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. TPPP/p25 promotes tubulin acetylation by inhibiting histone deacetylase 6 perhaps p25alpha plays a pro-aggregatory role in the common neurodegenerative disorders hall-marked by alpha-synuclein aggregates Recombinant TPPP plays an important role for tubulin-related transport in developing, myelinating oligodendrocytes. contribution of GSK3 in growth regulation of myeloma cells Data suggest that the intracellular level of TPPP/p25 influences the cell differentiation, proliferation and the formation of protein aggregates, and consequently, the etiology of central nervous system diseases. Binding of Zn(2) bivalent cation to structurally disordered TPPP/p25 influences TPPP/p25-promoted tubulin polymerization and GTPase activity. the central folded domain of TPPP/p25 following binding to microtubules can drive s homotypic protein-protein interactions leading to bundled microtubules. TPPP may have a role in poor prognosis in hepatocellular carcinoma

Pubmed identfication : 8275715 1639063

Synonyms : PSSALRE

WikiPathWays : Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways Regulation of Microtubule Cytoskeleton Glial Cell Differentiation