Bml 277 , CHK2 kinase inhibitor

Product name : Bml 277 , CHK2 kinase inhibitor

Catalog number : SIH-436-10MG

Supplier : StressMarq

Price : 10 EUR

Size : 165

More about:

Discovery year : 2001-09-19

Entrez Gene : checkpoint kinase 2  (CHEK2P2)

Entrez gene record : 11200

GenBank acession : AF086904

Gene : CHEK2

Gene ontology - Biological process : regulation of apoptotic process cell cycle protein stabilization phosphorylation intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator double-strand break repair cellular protein catabolic process response to gamma radiation replicative cell aging signal transduction involved in intra-S DNA damage checkpoint

Gene ontology - Cellular component : nucleus nucleoplasm Golgi apparatus chromosome, telomeric region PML body

Gene ontology - Molecular function : protein kinase activity protein serine/threonine kinase activity protein homodimerization activity kinase activity identical protein binding metal ion binding transferase activity nucleotide binding protein kinase binding ubiquitin protein ligase binding

Havana BLAST/BLAT : OTTHUMG00000151023

Identity : 16627

InterPro : Protein kinase domain  (PKDCC) Serine/threonine-protein kinase, active site Protein kinase-like domain SMAD/FHA domain Forkhead-associated (FHA) domain  (FHAD1) Calcium/calmodulin-dependent/calcium-dependent protein kinase  (CAMK1D)

Kegg : Cell cycle - Mus musculus (mouse) HTLV-I infection - Mus musculus (mouse) p53 signaling pathway - Mus musculus (mouse)

Locus : 22q12.1

Locus Specific Databases : LRG_302

Long gene name : checkpoint kinase 2

PubMed : Mitochondrial DNA damage initiates a cell cycle arrest by a Chk2-associated mechanism in mammalian cells. Ron overexpression on a Chk2*1100 deletion background accelerates the development of mammary tumors. These findings show, for the first time, that TLR9 engagement on CD4 T cells reduces IR-induced apoptosis by influencing cell-cycle checkpoint activity. Chk2 regulates apoptosis in both an ATM-dependent and an ATM-independent manner role of Chk2 in p53-dependent apoptotic response Chk2 inactivation is partially equivalent to p53 inactivation, in that Chk2 deficiency facilitates the development, survival, and proliferation of Brca1-deficient T cells at the expense of genomic integrity. Chk2 phosphorylation of S971 is involved in Brca1 function in modulating the DNA damage response and repressing tumor formation These data suggest that Chk2 suppresses the oncogenic potential of DNA damage arising during S and G2 phases of the cell cycle. Chk2 deficiency in Myc overexpressing lymphoma cells elicits a synergistic lethal response in combination with PARP inhibition. Results demonstrate that Chk2 plays important roles in regulating cell cycle progression during female meiosis and early embryo development.

Pubmed identfication : 9836640 10097108

RefSeq identity : NM_001005735

Synonyms : CDS1 CHK2 HuCds1 PP1425 bA444G7

Synonyms gene : RAD53

Synonyms gene name : CHK2 (checkpoint, S.pombe) homolog CHK2 checkpoint homolog (S. pombe)

WikiPathWays : Cell cycle miRNA regulation of DNA Damage Response