Bml 277 , CHK2 kinase inhibitor

Product name : Bml 277 , CHK2 kinase inhibitor

Catalog number : SIH-436-50MG

Supplier : StressMarq

Price : 50 EUR

Size : 508

More about:

Discovery year : 2001-09-19

Entrez Gene : checkpoint kinase 2  (CHEK2P2)

Entrez gene record : 11200

GenBank acession : AF086904

Gene : CHEK2

Gene ontology - Biological process : apoptotic process cell cycle peptidyl-serine phosphorylation cell division intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator negative regulation of cell cycle arrest DNA damage induced protein phosphorylation response to gamma radiation positive regulation of anoikis mitotic G2 phase

Gene ontology - Cellular component : nucleus nucleoplasm Golgi apparatus chromosome, telomeric region PML body

Gene ontology - Molecular function : protein kinase activity protein serine/threonine kinase activity ATP binding protein homodimerization activity kinase activity identical protein binding metal ion binding transferase activity nucleotide binding protein kinase binding

Havana BLAST/BLAT : OTTHUMG00000151023

Identity : 16627

InterPro : Protein kinase domain  (PKDCC) Serine/threonine-protein kinase, active site Protein kinase-like domain SMAD/FHA domain Forkhead-associated (FHA) domain  (FHAD1) Calcium/calmodulin-dependent/calcium-dependent protein kinase  (CAMK1D)

Kegg : Cell cycle - Mus musculus (mouse) HTLV-I infection - Mus musculus (mouse) p53 signaling pathway - Mus musculus (mouse)

Locus : 22q12.1

Locus Specific Databases : LRG_302

Long gene name : checkpoint kinase 2

PubMed : p53 is recruited into the PML nuclear bodies by PML along with chk2 new roles for several DNA damage response factors by demonstrating that they also participate in the oncogenic stress signaling pathway between E2F1 and p53 an important role for the DNA damage response mediated by ATR-Chk2 in p53 activation and renal cell apoptosis during cisplatin nephrotoxicity. Ron overexpression on a Chk2*1100 deletion background accelerates the development of mammary tumors. The role of P53 as part of the governing system that maintains the post-mitotic characteristic of differentiated neurons has been examined, with conditionally immortalized cortical cells obtained from null mice. Study show that mice carrying the variant CHEK2*1100delC allele not only are at an elevated risk for the development of cancer but also that this risk can be further increased as a result of environmental exposure. Results indicate that CHK2 mediates the induction of senescence in fibroblasts, but is dispensable for the induction of telomere dysfunction checkpoints at the stem and progenitor cell level in vivo. data indicate that an important role for Chk2 is maintaining lymphocyte development and that dual inactivation of Chk2 and Mus81 remarkably inhibits cancer Results represent the first demonstration of a role for CHK2 in the in vivo signaling of dysfunctional telomeres. We conclude that Chk2 regulates renal 25-hydroxyvitamin D 1alpha-hydroxylase expression thereby impacting on calcium and phosphate metabolism.

Pubmed identfication : 9836640 10097108

RefSeq identity : NM_001005735

Synonyms : CDS1 CHK2 HuCds1 PP1425 bA444G7

Synonyms gene : RAD53

Synonyms gene name : CHK2 (checkpoint, S.pombe) homolog CHK2 checkpoint homolog (S. pombe)

WikiPathWays : Cell cycle miRNA regulation of DNA Damage Response