BMP-11/GDF-11, human recombinant

Product name : BMP-11/GDF-11, human recombinant

Catalog number : 7155-10

Supplier : Biovision

Price : 240 EUR

Size : 10 μg

More about:

Classification : Piwi-interacting RNA clusters

Concept : Scope note: The initial culturing of cells derived directly from fresh TISSUES.

Discovery year : 2009-11-05

Entrez Gene : growth differentiation factor 11  (GDF11)

Entrez gene record : 100313791

GenBank acession : AF100907

Gene : PIRC52

Gene ontology - Biological process : ureteric bud development negative regulation of cell proliferation nervous system development positive regulation of pathway-restricted SMAD protein phosphorylation cell development SMAD protein signal transduction cell maturation negative regulation of cell differentiation mesoderm development spinal cord anterior/posterior patterning

Gene ontology - Cellular component : extracellular space nucleoplasm protein complex cellular_component intracellular membrane-bounded organelle

Gene ontology - Molecular function : protein binding growth factor activity cytokine activity transforming growth factor beta receptor binding

Havana BLAST/BLAT : OTTHUMG00000170188

Identity : 37556

InterPro : Transforming growth factor-beta, C-terminal Cystine-knot cytokine Transforming growth factor-beta-related Transforming growth factor beta, conserved site Transforming growth factor-beta, N-terminal

Locus : 11

Long gene name : piwi-interacting RNA cluster 52

Name : Primary Cell Culture

PubMed : GDF11 inhibits the activity of the peroxisome proliferator-activated receptor gamma by promoting its SUMOylation. Members of the transforming growth factor beta (TGFbeta) superfamily, bone morphogenetic protein 2 (BMP2), and growth and differentiation factor 11 (GDF11), can signal cultured RGCs to form dendrites. Differential antagonism of activin, myostatin and growth and differentiation factor 11 by wild-type and mutant follistatin. Both WFIKKN1 and WFIKKN2 have high affinity for growth and differentiation factors 8 and 11. These data demonstrate GDF11 to be a master regulator of neural stem cell transcription that can suppress cell proliferation and migration by regulating the expression of numerous genes involved in both these processes Expression of GDF11, a cytokine which blocks terminal erythroid maturation, was increased in erthyroblasts of thalassemic patients. in vitro sprout formation was increased as well by GDF11 treatment Show that there is no age-related cardiac hypertrophy in disease-free 24-month-old C57BL/6 mice and that restoring GDF11 in old mice has no effect on cardiac structure or function. The crystal structure of GDF11 was determined to a resolution of 1.50 A. GDF11 is highly concentrated in human platelets.

Pubmed identfication : 17881367

Qualifiers : classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics

Synonyms : BMP-11

Tree numbers : E01.370.225.500.223.500 E05.200.500.265.500 E05.242.223.500 E05.481.500.249.500